3',5'-dimethoxy-3-methyl-6-(prop-1-en-2-yl)biphenyl-2-ol | 1421367-07-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3',5'-dimethoxy-3-methyl-6-(prop-1-en-2-yl)biphenyl-2-ol
• 英文别名: 2-(3,5-Dimethoxyphenyl)-6-methyl-3-prop-1-en-2-ylphenol；2-(3,5-dimethoxyphenyl)-6-methyl-3-prop-1-en-2-ylphenol
• CAS: 1421367-07-8
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: DHIHLTUNUCIOCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-6-diazo-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enone 、 3,5-二甲氧基碘苯 在 potassium phosphate 、 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 22.0h， 以95%的产率得到3',5'-dimethoxy-3-methyl-6-(prop-1-en-2-yl)biphenyl-2-ol
  参考文献：
  名称：

  Facile Synthesis of 2-Arylphenols via Palladium-Catalyzed Cross-Coupling of Aryl Iodides with 6-Diazo-2-cyclohexenones

  摘要：

  2-Arylphenols were conveniently synthesized from aryl iodides and 6-diazo-2-cyclohexenones, In moderate to excellent yields, via tandem Pd-catalyzed cross-coupling/aromatization. The preliminary results for the corresponding enantioselective version showed that the coupling products could be generated In up to 72% ee.

  DOI：

  10.1021/ol303484f

文献信息

• Facile Synthesis of 2-Arylphenols via Palladium-Catalyzed Cross-Coupling of Aryl Iodides with 6-Diazo-2-cyclohexenones
  作者：Ke Yang、Jun Zhang、Yun Li、Bin Cheng、Liang Zhao、Hongbin Zhai

  DOI：10.1021/ol303484f

  日期：2013.2.15

  2-Arylphenols were conveniently synthesized from aryl iodides and 6-diazo-2-cyclohexenones, In moderate to excellent yields, via tandem Pd-catalyzed cross-coupling/aromatization. The preliminary results for the corresponding enantioselective version showed that the coupling products could be generated In up to 72% ee.