methyl 2-ethoxy-3-[4-(4-methanesulfonyloxybenzylamino) phenyl]propionate | 539813-68-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-ethoxy-3-[4-(4-methanesulfonyloxybenzylamino) phenyl]propionate
• 英文别名: Methyl 2-ethoxy-3-[4-(4-methanesulfonyloxybenzylamino)phenyl]propionate；methyl 2-ethoxy-3-[4-[(4-methylsulfonyloxyphenyl)methylamino]phenyl]propanoate
• CAS: 539813-68-8
• 化学式: C₂₀H₂₅NO₆S
• 分子量: 407.488
• InChiKey: SHDBPGDWHBPJPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  99.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl 2-ethoxy-3-(4-aminophenyl)propionate 、 4-formylphenyl methanesulfonate 在 对甲苯磺酸 、 盐酸 、 sodium cyanoborohydride 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 19.0h， 以37%的产率得到methyl 2-ethoxy-3-[4-(4-methanesulfonyloxybenzylamino) phenyl]propionate
  参考文献：
  名称：

  Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及具有化学式（I）的新型抗糖尿病、降血脂、抗肥胖和降胆固醇化合物，其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及含有它们的药学上可接受的组合物。

  公开号：

  US20030229083A1

文献信息

• COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Debnath Bhuniya

  公开号：US20070142470A1

  公开（公告）日：2007-06-21

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及一种新型抗糖尿病、降脂、抗肥胖和降胆固醇的化合物，其化学式为(I)，其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。
• ESTERS AND AMIDES AS PPAR-ALPHA AGONISTS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1453795A2

  公开（公告）日：2004-09-08
• US7314889B2
  申请人：——

  公开号：US7314889B2

  公开（公告）日：2008-01-01
• US7598293B2
  申请人：——

  公开号：US7598293B2

  公开（公告）日：2009-10-06
• [EN] NEW COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ET LEUR UTILISATION EN MEDECINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2003048116A2

  公开（公告）日：2003-06-12

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to compounds of the general formula (I) which are predominantly PPAR alpha agonists, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them The present invention also relates to processes for the preparation of novel compounds of formula (I), novel intermediates, processes for their preparation, use of the novel intermediates in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.