3-phenyl-4-<3,4-(methylenedioxyphenyl)methylene> isoxazol-5-one | 6286-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-phenyl-4-<3,4-(methylenedioxyphenyl)methylene> isoxazol-5-one
• 英文别名: (Z)-4-(benzo[d][1,3]dioxol-5-ylmethylene)-3-phenylisoxazol-5-(4H)-one；4-(Benzo[d][1,3]dioxol-5-ylmethylene)-3-phenylisoxazol-5(4H)-one；(4Z)-4-(1,3-benzodioxol-5-ylmethylidene)-3-phenyl-1,2-oxazol-5-one
• CAS: 6286-57-3
• 化学式: C₁₇H₁₁NO₄
• 分子量: 293.279
• InChiKey: HXPYADVNHOGEER-JYRVWZFOSA-N

物化性质

• 沸点：
  443.7±55.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯甲酰乙酸乙酯 在 aluminum oxide 、 potassium fluoride 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 0.07h， 生成 3-phenyl-4-<3,4-(methylenedioxyphenyl)methylene> isoxazol-5-one
  参考文献：
  名称：

  Potassium Fluoride on Alumina: Dry Condensation of 3-Phenylisoxazol-5-one with Aldehydes Under Microwave Irradiation

  摘要：

  3-Phenylisoxazol-5-one (2) and aromatic aldehydes were condensed to 3-phenyl-(4-arylmethylene) isoxazol-5-one (3) in the presence of Al(2)0(3)-KF without solvent under microwave irradiation.

  DOI：

  10.1080/00397919308013781

文献信息

• PEPTIDOMIMETIC MODULATORS OF CELL ADHESION
  申请人：Gour J. Barbara

  公开号：US20080081831A1

  公开（公告）日：2008-04-03

  Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cell adhesion recognition sequence HAV. Methods for using such peptidomimetics for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
• Bmp Gene and Fusion Protein
  申请人：Hidaka Chisa

  公开号：US20080260829A1

  公开（公告）日：2008-10-23

  This invention relates to BMP fusion genes, BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.
• US7268115B2
  申请人：——

  公开号：US7268115B2

  公开（公告）日：2007-09-11
• US7446120B2
  申请人：——

  公开号：US7446120B2

  公开（公告）日：2008-11-04
• Potassium Fluoride on Alumina: Dry Condensation of 3-Phenylisoxazol-5-one with Aldehydes Under Microwave Irradiation
  作者：Didier Villemin、Benoit Martin、Bernard Garrigues

  DOI：10.1080/00397919308013781

  日期：1993.8

  3-Phenylisoxazol-5-one (2) and aromatic aldehydes were condensed to 3-phenyl-(4-arylmethylene) isoxazol-5-one (3) in the presence of Al(2)0(3)-KF without solvent under microwave irradiation.