acetic acid-[2-(2-nitro-phenoxy)-anilide] | 107920-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetic acid-[2-(2-nitro-phenoxy)-anilide]
• 英文别名: Essigsaeure-[2-(2-nitro-phenoxy)-anilid]；(N-acetyl)aminophenyl nitrophenyl ether；N-[2-(2-nitrophenoxy)phenyl]acetamide
• CAS: 107920-35-4
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: VXORNAJQGCRDGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-溴-2-硝基苯 、 邻乙酰氨基酚 在 铜 作用下， 生成 acetic acid-[2-(2-nitro-phenoxy)-anilide]
  参考文献：
  名称：

  Expression of human hepatitis C virus core antigen in tobacco plants by tobacco mosaic virus-based vector system

  摘要：

  Tobacco mosaic virus (TMV) has the potential to highly express foreign gene. A novel TMV-based in trans expression system was constructed. A TMV mutant TSHc had its coat protein replaced with hepatitis C virus (HCV) core antigen gene. Another TMV mutant TSBD was replicase-detective. Coinfection of the two mutants could cause systemic infection in tobacco plants by in trans complementation of their functions. TSHc could effectively replicate and assemble to viral particles, which were a little longer than that of wild-type TMV. HCV core antigen was expressed in whole tobacco plants. A similar expression lever of HCV core antigen was detected on serial passages, which suggested that this viral expression system be stable.

  DOI：

  10.1007/bf02884901

文献信息

• Preparation of bis-(aminophenyl) ethers from (N-acetyl) aminophenols or their phenolates
  申请人：MALLINCKRODT, INC.(a Missouri corporation)

  公开号：EP0105660A1

  公开（公告）日：1984-04-18

  @ Bis-(aminophenyp ethers are prepared by effecting condensation reaction of an (N-acetyl)-aminophenol or the corresponding sodium or potassium (N-acetyl)-aminophenate with a halonitrobenzene under condensation reaction conditions to form an (N-acetyl)-aminophenyl nitrophenyl ether and hydrogenating the nitro group thereof under nitro- group hydrogenation conditions to form an (N-acetyl)-bis-(aminophenyl) ether. The latter compound is hydrolyzed with aqueous mineral acid under acid hydrolysis conditions to form an acidic aqueous dispersion of the bis-(aminophenyl) ether product, which can readily be recovered from the dispersion. Final bis-(aminophenyl) ether products thus prepared are typically of high purity and excellent colour properties, i.e., substantially colourless.

  在缩合反应条件下，(N-乙酰基)-氨基苯酚或相应的(N-乙酰基)-氨基苯酸钠或钾与卤化硝基苯发生缩合反应，生成(N-乙酰基)-氨基苯基硝基苯醚，并在硝基氢化条件下将其硝基氢化，生成(N-乙酰基)-双(氨基苯基)醚。后一种化合物在酸水解条件下与矿物酸水溶液进行水解，形成双（氨基苯基）醚产品的酸性水分散液，该分散液可以很容易地从分散液中回收。这样制备的最终双（氨基苯基）醚产品通常具有高纯度和极佳的颜色特性，即基本无色。
• US4551551A
  申请人：——

  公开号：US4551551A

  公开（公告）日：1985-11-05
• Expression of human hepatitis C virus core antigen in tobacco plants by tobacco mosaic virus-based vector system
  作者：Aidong Han、Yule Liu、Li Xiao、Liangyi Kang、Yuman Zhang、Dongtian Li、Bo Tian

  DOI：10.1007/bf02884901

  日期：2000.3

  Tobacco mosaic virus (TMV) has the potential to highly express foreign gene. A novel TMV-based in trans expression system was constructed. A TMV mutant TSHc had its coat protein replaced with hepatitis C virus (HCV) core antigen gene. Another TMV mutant TSBD was replicase-detective. Coinfection of the two mutants could cause systemic infection in tobacco plants by in trans complementation of their functions. TSHc could effectively replicate and assemble to viral particles, which were a little longer than that of wild-type TMV. HCV core antigen was expressed in whole tobacco plants. A similar expression lever of HCV core antigen was detected on serial passages, which suggested that this viral expression system be stable.