4-(4-methoxyphenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(4-methoxyphenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine
• 英文别名: 4-(4-Methoxyphenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
• 化学式: C₁₃H₁₁F₃N₂O₃S
• 分子量: 332.303
• InChiKey: PJDOGGJKMHCKOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] APOPTOSIS INHIBITORS<br/>[FR] INHIBITEURS DE L'APOPTOSE
  申请人：NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

  公开号：WO2018014802A1

  公开（公告）日：2018-01-25

  The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

  这项发明提供了一种抑制琥珀酸脱氢酶亚基B（SDHB）或共价修饰剂的化合物，以及抑制凋亡的化合物，以及这些化合物的药用盐、氢化物和立体异构体。这些化合物用于制备药物组合物，以及制备和使用方法，包括使用有效量的化合物或组合物治疗需要的人。
• Apoptosis inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US11034680B2

  公开（公告）日：2021-06-15

  The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

  本发明提供了琥珀酸脱氢酶亚基 B (SDHB) 的抑制剂或共价修饰剂和/或细胞凋亡抑制剂的化合物及其药学上可接受的盐、水合物和立体异构体。这些化合物可用于药物组合物以及制造和使用方法中，包括用有效量的化合物或组合物治疗有需要的人。
• APOPTOSIS INHIBITORS
  申请人：National Institute Of Biological Sciences, Beijing

  公开号：EP3484854B1

  公开（公告）日：2021-01-20
• Apoptosis Inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US20190152960A1

  公开（公告）日：2019-05-23

  The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.