(3R)-3-(aminomethyl)-4-[(3,4-dichlorophenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one | 714569-22-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R)-3-(aminomethyl)-4-[(3,4-dichlorophenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one
• 英文别名: (3R)-3-(aminomethyl)-4-(3,4-dichlorophenyl)sulfonyl-1,3-dihydroquinoxalin-2-one
• CAS: 714569-22-9
• 化学式: C₁₅H₁₃Cl₂N₃O₃S
• 分子量: 386.259
• InChiKey: KOOYOCNKEIBOGL-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]acetic acid 、 (3R)-3-(aminomethyl)-4-[(3,4-dichlorophenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 N({(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}methyl)-2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]acetamide
  参考文献：
  名称：

  [EN] NOVEL QUINOXALINONE DERIVATIVES AS BRADYKININ B1 ANTAGONISTS
  [FR] NOUVEAUX DERIVES DE QUINOXALINONE CONSTITUANT DES ANTAGONISTES B1 DE LA BRADYKININE

  摘要：

  2-喹啉酮衍生物是布雷金肽B1拮抗剂或逆向激动剂，在治疗或预防与布雷金肽B1途径相关的疼痛和炎症症状方面具有用处。

  公开号：

  WO2004054584A1
• 作为产物：
  描述：

  N-(2-硝基苯基)-O-苄基-D-丝氨酸甲酯 在 palladium on activated charcoal 氢气 、 甲基磺酰氯 、 三乙胺 作用下， 以 吡啶 、 乙醇 、 二氯甲烷 为溶剂， 20.0~80.0 ℃ 、379.22 kPa 条件下， 反应 104.5h， 生成 (3R)-3-(aminomethyl)-4-[(3,4-dichlorophenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one
  参考文献：
  名称：

  2-Quinoxalinone derivatives as bradykinin antagonists and novel compounds

  摘要：

  2-喹喔啉酮衍生物是布雷金肽B1拮抗剂或逆向激动剂，可用于治疗或预防与布雷金肽B1途径相关的症状，如疼痛和炎症。

  公开号：

  US20050020591A1

文献信息

• Novel quinoxalinone derivatives as bradykinin B1 antagonists
  申请人：——

  公开号：US20040132733A1

  公开（公告）日：2004-07-08

  2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

  2-喹喔啉酮衍生物是布雷金肽B1拮抗剂或逆向激动剂，可用于治疗或预防与布雷金肽B1途径相关的疼痛和炎症等症状。
• Quinoxalinone derivatives as bradykinin B1 antagonists
  申请人：Su Dai-Shi

  公开号：US06908921B2

  公开（公告）日：2005-06-21

  2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

  2-喹喔啉酮衍生物是Bradykinin B1拮抗剂或反向激动剂，在治疗或预防与Bradykinin B1通路相关的疼痛和炎症等症状方面有用。
• INHIBITORS AGAINST SODIUM ION ABSORPTION, AND PREVENTIVE OR THERAPEUTIC AGENTS AND FOODS CONTAINING THE SAME
  申请人：OTSUKA PHARMACEUTICAL FACTORY, INC.

  公开号：EP1249240A1

  公开（公告）日：2002-10-16

  The present invention provides a sodium ion absorption inhibitor comprising a metal salt, other than a sodium salt, of a cellulose derivatives represented by the following formula (I) as an active ingredient, whereby absorption of salt excessively present into a living body is effectively inhibited and salt excessively present is excreted outside the body positively and safely. Furthermore, the present invention provides an agent for preventing and treating diseases caused by excessive salt ingestion or diseases in which restriction on salt ingestion is required, comprising the same as an active ingredient, and foods comprising the same.         R-O-A     (I) (wherein R represents a cellulose residue and A represents a functional group having cation-exchange ability)

  本发明提供了一种钠离子吸收抑制剂，其有效成分包括下式(I)代表的纤维素衍生物的钠盐以外的金属盐，从而有效抑制生物体对过量盐的吸收，并积极安全地将过量盐排出体外。此外，本发明还提供了一种用于预防和治疗因摄入过多盐分而引起的疾病或需要限制摄入盐分的疾病的制剂，其中包含作为活性成分的纤维素衍生物，以及包含纤维素衍生物的食品。 R-O-A (I) (其中 R 代表纤维素残基，A 代表具有阳离子交换能力的官能团）
• Sodium ion absorption inhibitors, and preventive and therapeutic agents and foods containing the same
  申请人：Yamaoka Ippei

  公开号：US20050171056A1

  公开（公告）日：2005-08-04

  The present invention provides a sodium ion absorption inhibitor comprising a metal salt, other than a sodium salt, of a cellulose derivatives represented by the following formula (I) as an active ingredient, whereby absorption of salt excessively present into a living body is effectively inhibited and salt excessively present is excreted outside the body positively and safely. Furthermore, the present invention provides an agent for preventing and treating diseases caused by excessive salt ingestion or diseases in which restriction on salt ingestion is required, comprising the same as an active ingredient, and foods comprising the same. R—O—A   (I) (wherein R represents a cellulose residue and A represents a functional group having cation-exchange ability)

  本发明提供了一种钠离子吸收抑制剂，其有效成分包括下式(I)代表的纤维素衍生物的钠盐以外的金属盐，从而有效抑制生物体对过量盐的吸收，并积极安全地将过量盐排出体外。此外，本发明还提供了一种用于预防和治疗由摄入过多盐分引起的疾病或需要限制摄入盐分的疾病的制剂，其中包含作为活性成分的下式（I），以及包含下式（I）的食品。 R-O-A (I) (其中 R 代表纤维素残基，A 代表具有阳离子交换能力的官能团）
• Inhibitors against sodium ion absorption, and preventive or therapeutic agents and foods containing the same
  申请人：——

  公开号：US20030027789A1

  公开（公告）日：2003-02-06

  The present invention provides a sodium ion absorption inhibitor comprising a metal salt, other than a sodium salt, of a cellulose derivatives represented by the following formula (I) as an active ingredient, whereby absorption of salt excessively present into a living body is effectively inhibited and salt excessively present is excreted outside the body positively and safely. Furthermore, the present invention provides an agent for preventing and treating diseases caused by excessive salt ingestion or diseases in which restriction on salt ingestion is required, comprising the same as an active ingredient, and foods comprising the same. R-O-A  (I) (wherein R represents a cellulose residue and A represents a functional group having cation-exchange ability)