N-[(5-methylpyrazin-2-yl)methyl]-2-phenyl-6-(5-thiophen-2-ylpyridin-3-yl)pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[(5-methylpyrazin-2-yl)methyl]-2-phenyl-6-(5-thiophen-2-ylpyridin-3-yl)pyrimidin-4-amine
• 化学式: C₂₅H₂₀N₆S
• 分子量: 436.5
• InChiKey: OTSAVMJDCAUYAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR) AGONISTS<br/>[FR] COMPOSÉS PYRIMIDINE UTILISÉS COMME AGONISTES DU RÉCEPTEUR DE TYPE TOLL (TLR)
  申请人：COLEY PHARM GROUP INC

  公开号：WO2009030998A1

  公开（公告）日：2009-03-12

  Certain pyrimidine compounds are disclosed as Toll-like receptor (TLR) agonists. The compounds of the invention and pharmaceutical compositions including the compounds of the invention are useful for stimulating TLR signaling, specifically including signaling by TLR7, TLR8, and TLR9. The compounds and pharmaceutical compositions of the invention are also useful in methods for enhancing an immune response, for treating cancer, infection, allergy, and asthma, and for vaccinating a subject. The compounds and pharmaceutical compositions can be used alone, in combination with each other, in combination with an antigen, and in combination with additional therapeutic agents and modalities.