benzenecarboximidic acid 1-methylhydrazide | 157169-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzenecarboximidic acid 1-methylhydrazide
• 英文别名: N-amino-N-methylbenzenecarboximidamide
• CAS: 157169-65-8
• 化学式: C₈H₁₁N₃
• 分子量: 149.195
• InChiKey: IGBMRYVVCKKFJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzenecarboximidic acid 1-methylhydrazide 、 N,N'-bis(4-methoxyphenyl)ethane-bis(imidoyl) dichloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以47%的产率得到1-methyl-3-(4-methoxyphenylamino)-4-(4-methoxyphenylimino)-Δ²-1,2-diazetine
  参考文献：
  名称：

  A New Synthesis of 1,2-Diazetines via Simple Cycloacylation Reactions

  摘要：

  DOI：

  10.3987/com-02-9490

文献信息

• 3-deoxyglucosone and skin
  申请人：——

  公开号：US20030219440A1

  公开（公告）日：2003-11-27

  The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

  该发明涉及一种从皮肤中去除3-去氧葡萄糖酮和其他α-二酮糖的方法。该发明还涉及抑制皮肤中3-去氧葡萄糖酮和其他α-二酮糖的产生和功能的方法。该发明还涉及治疗与皮肤相关的3-去氧葡萄糖酮和其他α-二酮糖相关疾病和障碍的方法。
• Fructoseamine 3 kinase and the formation of collagen and elastin
  申请人：Tobia Annette

  公开号：US20070065443A1

  公开（公告）日：2007-03-22

  The invention relates to the discovery that levels of collagen and elastin can be modulated by changing the flux through the Amadori Pathway and that copper containing compounds and complexes inhibit the enzyme fructoseamine-3-kinase.

  本发明涉及到一项发现，即通过改变Amadori途径的通量可以调节胶原蛋白和弹性蛋白的水平，并且含铜化合物和配合物可以抑制酶果糖胺-3-激酶。
• Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof
  申请人：Brown R. Truman

  公开号：US20060089316A1

  公开（公告）日：2006-04-27

  Disclosed are methods of using various compounds, which are known to bind to 3-deoxyglucosone (3DG) or precursors thereof, in order to reduce a susceptibility to tumor formation and/or to prevent or delay onset of tumor formation induced by 3DG and its precursors. Also disclosed is the reduction of 3DG levels in high fructose corn syrop so that the high fructose corn syrup is less likely to induce tumor formation.

  公开了使用各种已知与3-脱氧葡萄糖酮（3DG）或其前体结合的化合物的方法，以减少对肿瘤形成的易感性和/或预防或延迟由3DG及其前体诱导的肿瘤形成。还公开了降低高果糖玉米糖浆中3DG水平的方法，以使高果糖玉米糖浆不太可能诱导肿瘤形成。
• Compounds for treating proliferative disorders
  申请人：Koya Keizo

  公开号：US20090023736A1

  公开（公告）日：2009-01-22

  Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

  本发明涉及化合物及其使用方法，用于治疗患有增殖性疾病（例如癌症）的受试者，以及用于治疗对Hsp70诱导和/或自然杀伤细胞诱导有反应的疾病的方法。此外，本发明还涉及包含本发明化合物和药用载体的制药组合物。
• COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
  申请人：Sun Lijun

  公开号：US20120065235A1

  公开（公告）日：2012-03-15

  Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

  本发明揭示了化合物及其使用方法，用于治疗患有增生性疾病（如癌症）的受试者，并用于治疗对Hsp70诱导和/或自然杀伤细胞诱导敏感的疾病的方法。此外，本发明还揭示了包含本发明化合物和药学上可接受的载体的制药组合物。