N-α-Phenethyl-N-benzylphenylamine | 16844-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-α-Phenethyl-N-benzylphenylamine
• 英文别名: N-Benzyl-N,1-diphenyl-aethylamin；N-benzyl-N-(1-phenylethyl)aniline
• CAS: 16844-16-9
• 化学式: C₂₁H₂₁N
• 分子量: 287.404
• InChiKey: OADSIGXZCLQXPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯基-(1-苯亚乙基)胺 、 溴甲苯 在 Bu₂SnClH-HMPA 作用下， 生成 N-α-Phenethyl-N-benzylphenylamine
  参考文献：
  名称：

  Highly Coordinated Tin Hydrides: A Novel Synthesis of Tertiary Amines via Hydrostannation of Imines

  摘要：

  The highly coordinated tin hydride, Bu(2)SnClH-HMPA (B), is shown to be an effective agent for the reduction of imines. The subsequent alkylation of the resulting intermediate tin amides permitted the preparation of a series of tertiary amines in a one-pot procedure. The spectral identification of the novel tin hydrides, B and Bu(2)SnClH-Bu(4)NF, was accomplished by H-1, C-13, and Sn-119 NMR and FT-IR studies.

  DOI：

  10.1021/jo00114a014

文献信息

• The alkali metal adducts of acetophenone anil
  作者：James G. Smith、C. Doreen Veach

  DOI：10.1139/v67-287

  日期：1967.8.1

  the reaction between acetophenone anil and sodium produces a product containing one atom of sodium per mole of anil. In its chemical behavior, this adduct appears to consist of equal parts of N-sodio-N,1-diphenylethylamine and α-sodioacetophenone anil. Thus, treatment with an alkyl halide results in products derived by alkylation of the nitrogen atom of N,1-diphenylethylamine and alkylation of the

  与之前的报道相反，苯乙酮苯胺和钠之间的反应产生的产物每摩尔苯胺含有一个钠原子。在其化学行为中，该加合物似乎由等量的 N-钠-N,1-二苯乙胺和 α-钠-苯乙酮苯胺组成。因此，用卤代烷处理会产生通过 N,1-二苯乙胺的氮原子烷基化和苯乙酮苯胺的甲基烷基化衍生的产物。苯乙酮苯胺对锂的行为完全不同并且非常依赖于溶剂。在醚中，锂加合物的水解产生二聚体 N,N',2,3-四苯基-2,3-丁二胺。在含有锂或钾的四氢呋喃中，另一种二聚体 N,N',l,4-四苯基-1,4-丁二胺通过苯乙酮苯胺的甲基进行二聚反应形成。
• Yoshikai, Naohiko; Mieczkowski, Adam; Matsumoto, Arimasa, Journal of the American Chemical Society, 2010, vol. 132, p. 5568 - 5569
  作者：Yoshikai, Naohiko、Mieczkowski, Adam、Matsumoto, Arimasa、Ilies, Laurean、Nakamura, Eiichi

  DOI：——

  日期：——
• Highly Coordinated Tin Hydrides: A Novel Synthesis of Tertiary Amines via Hydrostannation of Imines
  作者：Takayo Kawakami、Takayuki Sugimoto、Ikuya Shibata、Akio Baba、Haruo Matsuda、Noboru Sonoda

  DOI：10.1021/jo00114a014

  日期：1995.5

  The highly coordinated tin hydride, Bu(2)SnClH-HMPA (B), is shown to be an effective agent for the reduction of imines. The subsequent alkylation of the resulting intermediate tin amides permitted the preparation of a series of tertiary amines in a one-pot procedure. The spectral identification of the novel tin hydrides, B and Bu(2)SnClH-Bu(4)NF, was accomplished by H-1, C-13, and Sn-119 NMR and FT-IR studies.