Methyl-[1-(2-trimethylsilanylmethyl-phenyl)-ethyl]-amine | 1025825-45-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methyl-[1-(2-trimethylsilanylmethyl-phenyl)-ethyl]-amine
• 英文别名: N-methyl-1-[2-(trimethylsilylmethyl)phenyl]ethanamine
• CAS: 1025825-45-9
• 化学式: C₁₃H₂₃NSi
• 分子量: 221.418
• InChiKey: ZDFZGSSEIPOCMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Methyl-[1-(2-trimethylsilanylmethyl-phenyl)-ethyl]-amine 、 三氟乙酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,2,2-Trifluoro-N-methyl-N-[1-(2-trimethylsilanylmethyl-phenyl)-ethyl]-acetamide
  参考文献：
  名称：

  Exploring New Uses for C−H Amination:  Ni-Catalyzed Cross-Coupling of Cyclic Sulfamates

  摘要：

  Benzene-fused cyclic sulfamates are prepared from ortho-substituted phenolic starting materials through selective C-H amination or olefin aziridination. These unique heterocycles will engage in Ni-catalyzed cross-coupling reactions with aryl- and alkyl-Grignard reagents. Application of modern tools for C-N and C-C bond formation thus makes readily available functional amine derivatives and augments the possible uses for C-H amination in synthesis.

  DOI：

  10.1021/ol051896l
• 作为产物：
  描述：

  4-methyl-3,4-dihydro-benzo[e][1,2,3]oxathiazane-2,2-dioxide 在 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) 、 potassium carbonate 作用下， 以 乙醚 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 生成 Methyl-[1-(2-trimethylsilanylmethyl-phenyl)-ethyl]-amine
  参考文献：
  名称：

  Exploring New Uses for C−H Amination:  Ni-Catalyzed Cross-Coupling of Cyclic Sulfamates

  摘要：

  Benzene-fused cyclic sulfamates are prepared from ortho-substituted phenolic starting materials through selective C-H amination or olefin aziridination. These unique heterocycles will engage in Ni-catalyzed cross-coupling reactions with aryl- and alkyl-Grignard reagents. Application of modern tools for C-N and C-C bond formation thus makes readily available functional amine derivatives and augments the possible uses for C-H amination in synthesis.

  DOI：

  10.1021/ol051896l

文献信息

• Exploring New Uses for C−H Amination:  Ni-Catalyzed Cross-Coupling of Cyclic Sulfamates
  作者：Paul M. Wehn、J. Du Bois

  DOI：10.1021/ol051896l

  日期：2005.10.1

  Benzene-fused cyclic sulfamates are prepared from ortho-substituted phenolic starting materials through selective C-H amination or olefin aziridination. These unique heterocycles will engage in Ni-catalyzed cross-coupling reactions with aryl- and alkyl-Grignard reagents. Application of modern tools for C-N and C-C bond formation thus makes readily available functional amine derivatives and augments the possible uses for C-H amination in synthesis.