4-(2-fluorophenyl)-2-pyridin-3-yl-4,10-dihydropyrimido[1,2-a]benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(2-fluorophenyl)-2-pyridin-3-yl-4,10-dihydropyrimido[1,2-a]benzimidazole
• 化学式: C₂₁H₁₅FN₄
• 分子量: 342.4
• InChiKey: RFIGFWNJHNQWAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  42.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods of Inhibiting Bacterial Virulence and Compounds Relating Thereto
  申请人：Sperandio Vanessa

  公开号：US20100048573A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.

  本发明涉及化合物和方法，用于治疗细菌感染。由于它们的作用机制不涉及杀死细菌或抑制它们的生长，这些化合物诱导细菌耐药性的潜力被最小化。通过抑制细菌的毒力，本发明提供了治疗细菌感染的新方法。
• US8252841B2
  申请人：——

  公开号：US8252841B2

  公开（公告）日：2012-08-28
• [EN] METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO<br/>[FR] PROCÉDÉS D'INHIBITION DE LA VIRULENCE BACTÉRIENNE ET COMPOSÉS S'Y RAPPORTANT
  申请人：UNIV TEXAS

  公开号：WO2009088549A2

  公开（公告）日：2009-07-16

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.