2-(2'-methylphenylsulphonyl)benzamide | 77868-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2'-methylphenylsulphonyl)benzamide
• 英文别名: 2-(2-Methylphenyl)sulfonylbenzamide
• CAS: 77868-36-1
• 化学式: C₁₄H₁₃NO₃S
• 分子量: 275.328
• InChiKey: MONNNLMPBOIRAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  85.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(2'-Methylphenylthio)benzohydroxamic acid 在 PPA 、 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 2.25h， 生成 2-(2'-methylphenylsulphonyl)benzamide
  参考文献：
  名称：

  Dhareshwar, G. P.; Chhaya, P. N.; Hosangadi, B. D., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 10, p. 831 - 835

  摘要：

  DOI：

文献信息

• Aliphatic carboxamides
  申请人：ZENECA INC.

  公开号：EP0290145A1

  公开（公告）日：1988-11-09

  This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z-Y-X< is selected from >C=CH-N<, >N-CH=C<, >C=N-N< and >N-N=C< and the other radicals have the meanings defined in the following specifica­tion. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceuti­cally acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

  本发明提供了一系列式 I 的新型杂环脂肪族羧酰胺，其中基团 >Z-Y-XC=CH-NN-CH=CC=N-NN-N=C< 和其他基团的含义见以下说明书。式 I 的化合物是白三烯拮抗剂。本发明还提供了式 I 化合物的药学上可接受的盐；含有式 I 化合物或其盐的药物组合物，用于治疗例如过敏性或炎症性疾病，或内毒素性或创伤性休克病症；以及式 I 化合物的制造工艺和用于此类制造的中间体。
• Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists
  申请人：ICI AMERICAS INC.

  公开号：EP0337765A2

  公开（公告）日：1989-10-18

  This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R¹¹ and R¹² are defined in the specification) derived from acylsulfon­amide derivatives of α-carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharma­ceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

  本发明包括新颖的式 I 碳环化合物（其中 A、Z、R¹¹ 和 R¹² 在说明书中定义），该化合物衍生自 α-碳环甲苯酸的酰基磺酰胺衍生物，其中所述式 I 化合物可拮抗一种或多种称为白三烯的花生四烯酸代谢物的作用。本发明还提供了式 I 化合物的药学上可接受的盐；含有式 I 化合物或其盐的药物组合物，用于治疗例如过敏性或炎症性疾病，或内毒素性或创伤性休克病症；以及式 I 化合物的制造工艺和用于此类制造的中间体。
• Benzimidazole derivatives
  申请人：ZENECA LIMITED

  公开号：EP0399732A1

  公开（公告）日：1990-11-28

  The invention concerns heterocyclic compounds of the formula I (and their physiologically acceptable salts), together with pharmaceutical compositions containing them. The heterocyclic compounds antagonise the actions of angiotensin II and are of value in treating diseases or medical conditions such as hypertension and congestive heart failure in warm-blooded animals. The invention further includes processes for the manufacture of the compounds and their use in medical treatment.

  本发明涉及式 I 的杂环化合物（及其生理上可接受的盐类）以及含有它们的药物组合物。 (及其生理上可接受的盐）以及含有它们的药物组合物。这些杂环化合物能拮抗血管紧张素 II 的作用，对治疗温血动物的高血压和充血性心力衰竭等疾病或病症具有重要价值。本发明还包括化合物的制造工艺及其在医疗中的应用。
• A process for the preparation of 2(R)-methyl-4,4,4-trifluorobutylamine, intermediates, and a process for the preparation of a derivative thereof
  申请人：ZENECA LIMITED

  公开号：EP0489548B1

  公开（公告）日：1994-12-14
• A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof
  申请人：ZENECA LIMITED

  公开号：EP0489547B1

  公开（公告）日：1998-07-29