(S)-N-cyclohexylmethyl-N-(2-pyrrolidinylmethyl)amine | 1304023-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-N-cyclohexylmethyl-N-(2-pyrrolidinylmethyl)amine
• 英文别名: 1-cyclohexyl-N-[[(2S)-pyrrolidin-2-yl]methyl]methanamine
• CAS: 1304023-24-2
• 化学式: C₁₂H₂₄N₂
• 分子量: 196.336
• InChiKey: QFIXNWLSSUFQBU-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  S-叔丁氧羰基-2-(氨基乙基)吡咯烷 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 (S)-N-cyclohexylmethyl-N-(2-pyrrolidinylmethyl)amine
  参考文献：
  名称：

  Asymmetric Intramolecular Aldol Reaction Mediated by (S)-N-Substituted-N-(2-pyrrolidinylmethyl)amine to Prepare Wieland-Miescher Ketone

  摘要：

  New or known N-substituted-N-(2-pyrrolidinylmethyl)amine derivatives bearing a variety of alkyl and aryl substituents were easily prepared from N-Boc-proline or N'-Boc-N-(2-pyrrolidinylmethyl)amine. The enantioselectivity of the intramolecular asymmetric aldol reaction mediated by a combination of the amine derivative and TFA to prepare Wieland-Miescher ketone was examined. During the examination, optimal amount of TFA in the reaction was identified.

  DOI：

  10.3987/com-10-s(e)119

文献信息

• Asymmetric Intramolecular Aldol Reaction Mediated by (S)-N-Substituted-N-(2-pyrrolidinylmethyl)amine to Prepare Wieland-Miescher Ketone
  作者：Kohei Inomata、Yuichi Akahane、Yasuyuki Endo

  DOI：10.3987/com-10-s(e)119

  日期：——

  New or known N-substituted-N-(2-pyrrolidinylmethyl)amine derivatives bearing a variety of alkyl and aryl substituents were easily prepared from N-Boc-proline or N'-Boc-N-(2-pyrrolidinylmethyl)amine. The enantioselectivity of the intramolecular asymmetric aldol reaction mediated by a combination of the amine derivative and TFA to prepare Wieland-Miescher ketone was examined. During the examination, optimal amount of TFA in the reaction was identified.