2-(p-Biphenyl)-7-methyl-4H-1,2,4-triazolo<1,5-a>pyridin | 65966-05-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(p-Biphenyl)-7-methyl-4H-1,2,4-triazolo<1,5-a>pyridin
• 英文别名: 2-biphenyl-4-yl-7-methyl-[1,2,4]triazolo[1,5-a]pyridine；7-Methyl-2-(4-phenylphenyl)-[1,2,4]triazolo[1,5-a]pyridine
• CAS: 65966-05-4
• 化学式: C₁₉H₁₅N₃
• 分子量: 285.348
• InChiKey: XJBTYLZKRTVQLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(p-Biphenyl)-7-methyl-4H-1,2,4-triazolo<1,5-a>pyridin 以49%的产率得到
  参考文献：
  名称：

  PAUCHARD J.-P.; SIEGRIST A. E., HELV. CHIM. ACTA , 1978, 61, NO 1, 142-170

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氰基联苯 、 1-amino-4-methylpyridin-1-ium 2,4,6-trimethylbenzenesulfonate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以77%的产率得到2-(p-Biphenyl)-7-methyl-4H-1,2,4-triazolo<1,5-a>pyridin
  参考文献：
  名称：

  Non-steroidal Pregnancy-Terminating Agents: Design, Synthesis and Structure–Activity Relationships of 2-Aryl-1,2,4-triazolo[1,5-a]pyridine

  摘要：

  The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00399-2

文献信息

• 12. Anil-Synthese. 17. Mitteilung. Über die Herstellung von styryl-derivaten des 2-phenyl-4<i>H</i>-1,2,4-triazolo [1,5-<i>a</i>]pyridins
  作者：Jean-Paul Pauchard、Adolf Emil Siegrist

  DOI：10.1002/hlca.19780610115

  日期：1978.1.25

  Preparation of styryl derivatives of 2-phenyl-4H-1,2,4-triazolo [1,5-a]pyridine

  2-苯基-4 H -1,2,4-三唑并[1,5- a ]吡啶的苯乙烯基衍生物的制备
• Non-steroidal Pregnancy-Terminating Agents: Design, Synthesis and Structure–Activity Relationships of 2-Aryl-1,2,4-triazolo[1,5-a]pyridine
  作者：Tao Liu、Yongzhou Hu

  DOI：10.1016/s0960-894x(02)00399-2

  日期：2002.9

  The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.
• PAUCHARD J.-P.; SIEGRIST A. E., HELV. CHIM. ACTA <HCAC-AV>, 1978, 61, NO 1, 142-170
  作者：PAUCHARD J.-P.、 SIEGRIST A. E.

  DOI：——

  日期：——