Diphenyl-4-carbaldehyd-semicarbazon | 2920-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diphenyl-4-carbaldehyd-semicarbazon
• 英文别名: biphenyl-4-carbaldehyde-semicarbazone；Biphenyl-4-carbaldehyd-semicarbazon；[(4-Phenylphenyl)methylideneamino]urea
• CAS: 2920-40-3
• 化学式: C₁₄H₁₃N₃O
• mdl: MFCD04512790
• 分子量: 239.277
• InChiKey: ZRPPHYTVKRBQES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氰基联苯 在 盐酸 、 乙醚 、 tin(ll) chloride 作用下， 生成 Diphenyl-4-carbaldehyd-semicarbazon
  参考文献：
  名称：

  13.对称黑社会质子系统。第九部分 在流动性和平衡的多核芳基的在影响αγ -diarylmethylene偶氮甲碱系

  摘要：

  DOI：

  10.1039/jr9330000037

文献信息

• Some aryl semicarbazones possessing anticonvulsant activitie
  作者：JR Dimmock、KK Sidhu、SD Tumber、SK Basran、M Chen、JW Quail、J Yang、I Rozas、DF Weaver

  DOI：10.1016/0223-5234(96)88237-7

  日期：——

  A number of aryl semicarbazones displayed anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens when administered intraperitoneally to mice. When given by the oral route to rats, protection was afforded in the MES but not scPTZ tests. Correlations were noted between the sigma and sigma* values of the aryl substituents, the interplanar angles made by the aryl rings with the adjacent carbimino groups and the shapes of certain semicarbazones determined by X-ray crystallography, and the activities in the rat oral MES screen. Molecular modeling studies revealed a number of statistically significant descriptors which contributed to anticonvulsant activity.
• 13. Symmetrical triad prototropic systems. Part IX. The influence of polynuclear aryl groups upon mobility and equilibrium in the αγ-diarylmethyleneazomethine system
  作者：Charles W. Shoppee

  DOI：10.1039/jr9330000037

  日期：——