苯并[E][1,3]苯并噻唑 | 233-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并噻唑类
• 中文名称: 苯并[E][1,3]苯并噻唑
• 英文名称: naphtho<1,2-d>thiazole
• 英文别名: Naphtho[1,2-d]thiazole；benzo[e][1,3]benzothiazole
• CAS: 233-74-9
• 化学式: C₁₁H₇NS
• mdl: MFCD09837249
• 分子量: 185.249
• InChiKey: KXNQKOAQSGJCQU-UHFFFAOYSA-N

物化性质

• 熔点：
  53-54 °C
• 沸点：
  347.0±11.0 °C(Predicted)
• 密度：
  1.319±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  苯并[E][1,3]苯并噻唑 在 正丁基锂 、 sodium hydroxide 作用下， 以 四氢呋喃 、 正己烷 、 丙酮 为溶剂， 反应 19.83h， 生成 (E)-2-(1-(hex-2-en-1-yloxy)-3-methylbutyl)naphtho[1,2-d]thiazole
  参考文献：
  名称：

  区域分歧维蒂希重排产品的可移动功能组策略

  摘要：

  [1,2]和[2,3]维蒂希重排是竞争性反应途径，通常导致不可控制的产物分布。我们采用一个可移动的官能团来实现获得[1,2,3]路径的可逆[2,3]和稳定自由基中间体的双重作用，从而有选择地获得两种Wittig产物，可广泛用于多种基质。

  DOI：

  10.1039/c8ob02221f
• 作为产物：
  描述：

  ethyl 2-(1-naphthylamino)-2-oxoacetate 在 sodium hydroxide 、 tetraphosphorus decasulfide 、 xylene 、 potassium hexacyanoferrate(III) 作用下， 生成 苯并[E][1,3]苯并噻唑
  参考文献：
  名称：

  Boggust et al., Journal of the Chemical Society, 1950, p. 680

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES<br/>[FR] COMPOSÉS PRÉSENTANT DES PROPRIÉTÉS ÉLECTROLUMINESCENTES OU DE TRANSPORT DES ÉLECTRONS
  申请人：MERCK PATENT GMBH

  公开号：WO2009112854A1

  公开（公告）日：2009-09-17

  A compound of the formula R1 (CR3 =CR4 ) nAr(CR4 =CR3 ) nR2 wherein: n is 0 or 1; Ar represents aryl or heteroaryl having 1-5 aromatic rings which may be chain or fused or a combination of chain and fused, which may be substituted withalkoxy, fluoro, fluoroalkyl or cyano and which in the case of a 5-memnered ring nitrogen heteroatom may be N-substituted with aryl or substituted aryl optionally further substituted with alkoxy, fluoro, fluoroalkyl or cyano; R1 and R2 independently represent aryl or nitrogen, oxygen or sulphur-containing heteroaryl having two to four fused aromatic rings one of which may be 5-membered and optionally substituted by aryl or heteroaryl having 1-5 chain or fused aromatic rings which may be further substituted withalkoxy, fluoro, fluoroalkyl or cyano; and R3 and R4 independently represent hydrogen, methyl, ethyl or benzyl. Alsoprovided is a method of making a compound having electroluminescent and/or electroconductive properties, which comprises condensing an aromatic dialdehyde with a methyl-substituted heteroaryl compound having two to four fused rings which maybe unsubstituted ormay be further substituted by aryl or heteroaryl having from one to fouraromatic rings, said aryl or heteroaryl substituent or substituents optionally being substituted with one or more fluoro, fluoroalkyl orcyano substituents.The condensation may be carried out in acetic anhydride under reflux. The compounds may be incorporatede.g. as an electron transport layer into an optical light emitting diode,where embodiments can provide high electron mobility, low turn-on voltage and good lifetime,or into an electrostatic imaging member. Acompositionis provided comprising a compound as above and a second host or electron transport material and/or at leastone dopant.

  一个化合物的结构式为R1（CR3=CR4）nAr（CR4=CR3）nR2，其中：n为0或1；Ar代表含有1-5个芳香环的芳基或杂芳基，可以是链状的、融合的或链状和融合的组合，可以被烷氧基、氟、氟烷基或氰基取代，在5-成员环氮杂原子的情况下，可能被芳基或取代芳基N-取代，可选择地进一步取代为烷氧基、氟、氟烷基或氰基；R1和R2独立地代表含有两到四个融合芳香环的芳基或氮、氧或硫杂杂芳基，其中一个可能是5-成员的，并且可选择地被芳基或含有1-5个链状或融合芳香环的杂芳基取代，这些芳基或杂芳基可能进一步被烷氧基、氟、氟烷基或氰基取代；R3和R4独立地代表氢、甲基、乙基或苄基。还提供了一种制备具有电致发光和/或电导性能的化合物的方法，包括将芳香二醛与一种具有两到四个融合环的甲基取代的杂芳基化合物缩合，该化合物可能未取代或可能进一步被含有一到四个芳香环的芳基或杂芳基取代，所述芳基或杂芳基取代物可选择地被一个或多个氟、氟烷基或氰基取代。缩合可以在乙酸酐中回流进行。这些化合物可以被用作电子传输层，例如用于光电发光二极管，其中实施例可以提供高电子迁移率、低开启电压和良好的寿命，或用于静电成像成员。提供了一种组合物，包括上述化合物和第二宿主或电子传输材料和/或至少一个掺杂剂。
• Process for producing carbonyl compound
  申请人：Mizushima Eiichiro

  公开号：US20050143597A1

  公开（公告）日：2005-06-30

  The present invention relates to a process which comprises efficiently proceeding a hydration reaction of an alkyne in aspects of turnover numbers of a catalyst, yield and speed to thereby industrially and advantageously produce the corresponding carbonyl compound. The present invention provides a process for producing a carbonyl compound, which comprises reacting an alkyne compound with water in the presence of a gold catalyst which is an organogold complex compound and acid in an organic solvent.

  本发明涉及一种工艺，其包括高效地进行炔烃的水合反应，以在催化剂的周转次数、产率和速度方面从而在工业上和有利地生产相应的羰基化合物。本发明提供了一种生产羰基化合物的工艺，其中在有机溶剂中，在存在金催化剂（一种有机金配合物）和酸的情况下，将炔烃化合物与水反应。
• Method and composition for rejuvinating cells, tissues organs, hair and nails
  申请人：——

  公开号：US20020188015A1

  公开（公告）日：2002-12-12

  In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

  在一个实施例中，本发明涉及包含药物组合物的化合物和组合物，其中药物组合物包含这些化合物，并且相关方法解耦蛋白质、脂质、核酸和其他生物材料以及它们的任意组合的糖介导偶联。在另一个实施例中，这些组合物和相关方法在体内具有实用性，用于减少生物体暴露于内部摄入、经皮应用或其他方式的化合物或组合物时，糖介导偶联过程的有害影响。在另一个实施例中，这些组合物和相关方法对器官、细胞和组织的离体处理以及头发、指甲和皮肤的外部处理具有用处，通过改变可变性和增加组织扩散系数来使它们恢复活力。在另一个实施例中，本发明涉及新颖的化合物和药物组合物。
• Metallic Compound and Organic Electroluminescence Device Comprising the Same
  申请人：Suh Dong-Hack

  公开号：US20080200678A1

  公开（公告）日：2008-08-21

  The present invention relates to a light-emitting transition metal compound represented by the Chemical Formula 1 and Chemical Formula 2 and an organic electroluminescence device including the same. In the Chemical Formulae 1 and 2, M is Ir, Pt, Rh, Re, Os, and the like, m is 2 or 3, n is 0 or 1, the sum of m and n is 3, provided that the sum of m and n is 2 when M is Pt, X, and Z are the same or different, N or P, and Y and Q are O, S, or Se, R 1 and R 5 are hydrogen, a C1 to C20 alkyl excluding an aromatic cyclic substituent, a cycloalkyl, a halogen, a linear or branched substituent including at least one halogen, or a linear or branched substituent including at least one heteroatom, and R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 , and R 10 are hydrogen, a C1 to C20 alkyl, an aryl, a cycloalkyl, a halogen, a linear or branched substituent including at least one halogen, a linear or branched substituent including at least one heteroatom, carbonyl, vinyl, or acetylenyl, or may form a cycle, and may be the same or different.

  本发明涉及一种由化学式1和化学式2表示的发光过渡金属化合物，以及包括该化合物的有机电致发光器件。在化学式1和2中，M为Ir、Pt、Rh、Re、Os等，m为2或3，n为0或1，m和n的总和为3，当M为Pt时，m和n的总和为2，X和Z相同或不同，为N或P，Y和Q为O、S或Se，R1和R5为氢、除芳香环取代基外的C1到C20烷基、环烷基、卤素、线性或支链取代基，包括至少一个卤素，或包括至少一个杂原子的线性或支链取代基，R2、R3、R4、R6、R7、R8、R9和R10为氢、C1到C20烷基、芳基、环烷基、卤素、线性或支链取代基，包括至少一个卤素，线性或支链取代基，包括至少一个杂原子，羰基、烯基或乙炔基，或可形成环，并且可以相同或不同。
• Methods for reducing uric acid levels
  申请人：——

  公开号：US20010044437A1

  公开（公告）日：2001-11-22

  Disclosed are methods of reducing serum uric acid levels, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of gout and related diseases. Also disclosed are pharmaceutical compositions containing the compounds.

  揭示了降低血清尿酸水平的方法，该方法包括向需要此类治疗的患者施用取代的吲哚烷基酸。还揭示了这些化合物在痛风和相关疾病治疗中的用途。还揭示了含有这些化合物的药物组合物。