2-bromo-5-(5-cyano-spiro[2,3]hex-5-yl) pyridine | 959926-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-bromo-5-(5-cyano-spiro[2,3]hex-5-yl) pyridine
• 英文别名: 5-(6-Bromopyridin-3-yl)spiro[2.3]hexane-5-carbonitrile；5-(6-bromopyridin-3-yl)spiro[2.3]hexane-5-carbonitrile
• CAS: 959926-26-2
• 化学式: C₁₂H₁₁BrN₂
• 分子量: 263.137
• InChiKey: ZUYYYOHJNZPGFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-5-(5-cyano-spiro[2,3]hex-5-yl) pyridine 在 二氧化锰 作用下， 以 正庚烷 、 乙酸乙酯 为溶剂， 以75%的产率得到5-(5-aminocarbonyl-spiro[2,3]hex-5-yl)-2-bromopyridine
  参考文献：
  名称：

  EP2025676

  摘要：

  公开号：

文献信息

• NOVEL INDAZOLE DERIVATIVE HAVING SPIRO RING STRUCTURE IN SIDE CHAIN
  申请人：Ube Industries, Ltd.

  公开号：EP2025676A1

  公开（公告）日：2009-02-18

  An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 and R2 represent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; R3 represents halogen, H or the like; R4 and R5 represent halogen, H or the like; R6 and R7 represent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.

  本发明的目的是创造一种侧链具有螺环结构的新型吲唑衍生物，该衍生物可用作药物，并寻找该衍生物的新药理活性。本发明化合物由通式[I]表示，具有优异的 Rho 激酶抑制活性。式中，环 X 代表苯环或吡啶环；R1 和 R2 代表卤素、H、OH、烷氧基、环烷氧基、芳氧基、烷基、环烷基或类似物；R3 代表卤素、H 或类似物；R4 和 R5 代表卤素、H 或类似物；R6 和 R7 代表 H、烷基或类似物；m、n、p 和 q 代表 0 至 3 的整数。
• Novel indazole derivative having spiro ring structure in side chain
  申请人：Hagihara Masahiko

  公开号：US20090170887A1

  公开（公告）日：2009-07-02

  An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 and R 2 represent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; R 3 represents halogen, H or the like; R 4 and R 5 represent halogen, H or the like; R 6 and R 7 represent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.
• US8227480B2
  申请人：——

  公开号：US8227480B2

  公开（公告）日：2012-07-24
• EP2025676
  申请人：——

  公开号：——

  公开（公告）日：——