EDDP高氯酸盐标准品 | 31161-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: EDDP高氯酸盐标准品
• 英文名称: (+/-)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate
• 英文别名: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidinium perchlorate；(+/-)-2-Aethyl-1,5-dimethyl-3,3-diphenyl-4,5-dihydro-3H-pyrrolium-perchlorat；2-Ethyliden-1,5-dimethyl-3,3-diphenyl-4,5-dihydro-3H-pyrrolium-perchlorat；EDDP Perchlorate; 2-Ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium Perchlorate; 5-Ethyl-3,4-dihydro-1,2-dimethyl-4,4-diphenyl-2H-pyrrolium perchlorate (1:1)；5-ethyl-1,2-dimethyl-4,4-diphenyl-2,3-dihydropyrrol-1-ium;perchlorate
• CAS: 31161-17-8
• 化学式: C₂₀H₂₄N*ClO₄
• 分子量: 377.868
• InChiKey: FICCBMGBBWWZRF-UHFFFAOYSA-M

物化性质

• 闪点：
  9℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• WGK Germany：
  2

反应信息

• 作为反应物：
  描述：

  EDDP高氯酸盐标准品 在 sodium hydroxide 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 12.0h， 生成 2,3-dimethyl-5,5-diphenyl-2-cyclopentenone
  参考文献：
  名称：

  Characterization of new oxidation products of the perchlorate salt of the methadone metabolite,(±)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)

  摘要：

  DOI：

  10.1016/s0040-4020(01)87424-x

文献信息

• Composition for Treatment of Pain Specification
  申请人：Friedman S. Robert

  公开号：US20080096872A1

  公开（公告）日：2008-04-24

  A method for the treatment of pain and/or inflammation in a subject by the administration of N-acetyl-cysteine (NAC) or derivative thereof and a pain and/or anti-inflammatory medication. The pain or anti-inflammatory medication is metabolized by the action of the cytochrome p450 system. The pain medication includes N-methyl-D-aspartate (NMDA) receptor antagonist(s). NAC and the pain medicine can be administered concurrently or sequentially. The joint administration can result in the use of lower dosages than typical dosage of the pain and/or anti-inflammatory medication or in enhanced relief from the treated condition.
• [EN] COMPOSITION FOR TREATMENT OF PAIN SPECIFICATION<br/>[FR] COMPOSITION POUR TRAITEMENT DE LA DOULEUR
  申请人：FRIEDMAN ROBERT S

  公开号：WO2006069293A2

  公开（公告）日：2006-06-29

  [EN] A method for the treatment of pain and/or inflammation in a subject by the administration of N-acetyl-cysteine (NAC) or derivative thereof and a pain and/or anti-inflammatory medication. The pain or anti-inflammatory medication is metabolized by the action of the cytochrome p450 system. The pain medication includes N-methyl-D-aspartate (NMDA) receptor antagonist(s). NAC and the pain medicine can be administered concurrently or sequentially. The joint administration can result in the use of lower dosages than typical dosage of the pain and/or anti-inflammatory medication or in enhanced relief from the treated condition.
  [FR] Méthode de traitement de la douleur et/ou d'une inflammation chez un sujet, consistant à administrer une N-acétyl-cystéine (NAC) ou un dérivé de ce composé et un médicament analgésique et/ou anti-inflammatoire. Ledit médicament analgésique ou anti-inflammatoire est métabolisé par l'action du système à cytochrome p450. L'analgésique contient un ou des antagonistes du récepteur de N-méthyl-D-aspartate (NMDA). Le composé NAC et le médicament analgésique peuvent être administrés conjointement ou l'un après l'autre. L'administration conjointe peut permettre de réduire la dose normale du médicament analgésique et/ou anti-inflammatoire ou bien procurer un soulagement plus marqué.
• Characterization of new oxidation products of the perchlorate salt of the methadone metabolite,(±)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)
  作者：Frank S. Abbott、J.Gregory Slatter、Gun Il Kang

  DOI：10.1016/s0040-4020(01)87424-x

  日期：1986.1