rac-<1-(6-bromopyridin-2-yl)-2,2-dimethylpropyl>methyl ether | 127127-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: rac-<1-(6-bromopyridin-2-yl)-2,2-dimethylpropyl>methyl ether
• 英文别名: rac-1-(6-Bromopyridin-2-yl)-2,2-dimethylpropyl methyl ether；2-Bromo-6-(1-methoxy-2,2-dimethylpropyl)pyridine
• CAS: 127127-32-6
• 化学式: C₁₁H₁₆BrNO
• 分子量: 258.158
• InChiKey: YOSMMSUSMDFZRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  rac-<1-(6-bromopyridin-2-yl)-2,2-dimethylpropyl>methyl ether 在 copper(I) oxide 氨 作用下， 以 乙二醇 为溶剂， 反应 24.0h， 以68%的产率得到6-(1-methoxy-2,2-dimethylpropyl)pyridin-2-amine
  参考文献：
  名称：

  通过铜和钯催化高效，经济地合成新的取代氨基-双吡啶基衍生物

  摘要：

  介绍了一种合成各种氨基双吡啶基化合物的简便方法。通过商业上可得的2,6-二溴吡啶，通过铜介导的烷基化，然后分别由铜和钯催化的两个连续的N-芳基化反应，分三步制备双吡啶胺。

  DOI：

  10.1016/j.tetlet.2008.03.096
• 作为产物：
  描述：

  2,6-二溴吡啶 在 正丁基锂 、 sodium hydride 作用下， 反应 5.42h， 生成 rac-<1-(6-bromopyridin-2-yl)-2,2-dimethylpropyl>methyl ether
  参考文献：
  名称：

  Bolm, Carsten; Ewald, Martina; Felder, Marcel, Chemische Berichte, 1992, vol. 125, # 5, p. 1169 - 1190

  摘要：

  DOI：

文献信息

• Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives
  作者：Vincent Levacher、Christina Moberg

  DOI：10.1021/jo00111a038

  日期：1995.3

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.
• Bolm, Carsten; Ewald, Martina; Felder, Marcel, Chemische Berichte, 1992, vol. 125, # 5, p. 1169 - 1190
  作者：Bolm, Carsten、Ewald, Martina、Felder, Marcel、Schlingloff, Gunther

  DOI：——

  日期：——
• Highly efficient and economic synthesis of new substituted amino-bispyridyl derivatives via copper and palladium catalysis
  作者：Sylvain Gaillard、Mohammed Kamal Elmkaddem、Cédric Fischmeister、Christophe M. Thomas、Jean-Luc Renaud

  DOI：10.1016/j.tetlet.2008.03.096

  日期：2008.5

  A convenient route for the synthesis of a variety of amino-bispyridyl compounds is introduced. Bispyridylamines were prepared in three steps from commercially available 2,6-dibromopyridine, via a copper mediated alkylation followed by two consecutive N-arylation reactions catalyzed by copper and palladium, respectively.

  介绍了一种合成各种氨基双吡啶基化合物的简便方法。通过商业上可得的2,6-二溴吡啶，通过铜介导的烷基化，然后分别由铜和钯催化的两个连续的N-芳基化反应，分三步制备双吡啶胺。