2-(1-Methyl-1H-imidazol-4-yl)-pyridine | 93764-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(1-Methyl-1H-imidazol-4-yl)-pyridine
• 英文别名: 2-(1-Methylimidazol-4-yl)pyridine
• CAS: 93764-57-9
• 化学式: C₉H₉N₃
• mdl: MFCD09908720
• 分子量: 159.191
• InChiKey: UBHNAQKCQMFVCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘吡啶 、 N-甲基咪唑 、 二氯甲烷 生成 2-(1-Methyl-1H-imidazol-4-yl)-pyridine
  参考文献：
  名称：

  SEKI, KOH-ICHI;OHKURA, KAZUE;TERASHIMA, MASANAO;KANAOKA, YUICHI, HETEROCYCLES, 1984, 22, N 10, 2347-2350

  摘要：

  DOI：

文献信息

• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Genentech, Inc.

  公开号：US20150065522A1

  公开（公告）日：2015-03-05

  The present invention relates to compounds formula (I): and to salts thereof, wherein R 1 -R 4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及化合物的化学式（I）及其盐，其中R1-R4和A具有规范中定义的任何值，以及这些化合物的组合物和用途。这些化合物可用作组蛋白去甲基化酶的抑制剂，如KDM5。还包括包含本发明化合物的药用可接受组合物，以及使用这些组合物治疗各种疾病的方法。
• Improved redox couple for electrochemical and optoelectronic devices
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：EP2492277A1

  公开（公告）日：2012-08-29

  The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising a substituted or unsubstituted ring or ring system comprising a five-membered N-containing heteroring and/or a six-membered ring comprising at least two heteroatoms, at least one of which being a nitrogen atom, said five- or six-membered heteroring, respectively, comprising at least one double bond. The invention also relates to electrolytes and to the devices containing the complex, and to the use of the complex as a redox couple.

  本发明提供了一种改进的氧化还原偶对，用于电化学和光电子器件。该氧化还原偶对基于第一行过渡金属的配合物，所述配合物至少含有一个单、双或三齿配体，包括一个取代或未取代的环或环系统，其中包括一个五元N-含杂环和/或一个至少含有两个杂原子的六元环，其中至少一个是氮原子，所述的五元或六元杂环分别包括至少一个双键。该发明还涉及电解质、含有该配合物的器件，以及将该配合物用作氧化还原偶对的用途。
• REDOX COUPLE FOR ELECTROCHEMICAL AND OPTOELECTRONIC DEVICES
  申请人：Nazeeruddin Mohammad Khaja

  公开号：US20140060641A1

  公开（公告）日：2014-03-06

  The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising a substituted or unsubstituted ring or ring system comprising a five-membered N-containing heteroring and/or a six-membered ring comprising at least two heteroatoms, at least one of which being a nitrogen atom, said five- or six-membered heteroring, respectively, comprising at least one double bond. The invention also relates to electrolytes and to the devices containing the complex, and to the use of the complex as a redox couple. The invention further provides electrochemical and/or optoelectronic devices comprising a first and a second electrode and, between said first and second electrode, a charge transport layer, said a charge transport layer comprising tetracyanoborate ([B(CN) 4 ] − ) and a cationic metal complex functioning as redox-couple.

  本发明提供了一种改进的氧化还原偶对，用于电化学和光电子器件。该氧化还原偶对基于第一行过渡金属的配合物，该配合物包含至少一种单、双或三齿配体，包括一个取代或未取代的环或环系统，其中包括一个含氮的五元杂环和/或至少包含两个杂原子的六元环，其中至少一个是氮原子，该五元或六元杂环，分别包括至少一个双键。本发明还涉及电解质、含有该配合物的器件以及将该配合物用作氧化还原偶对的用途。本发明进一步提供了电化学和/或光电子器件，包括第一和第二电极，以及在该第一和第二电极之间的电荷传输层，该电荷传输层包括四氰硼酸盐([B(CN)4]−)和作为氧化还原偶对的阳离子金属配合物。
• METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES
  申请人：Ecole Polytechnique Federale de Lausanne (EPFL)

  公开号：US20160233439A1

  公开（公告）日：2016-08-11

  The invention relates to electrochemical devices comprising complexes of cobalt comprising at least one ligand with a 5- or six membered, N-containing heteroring. The complex are useful as p- and n-dopants, as over of electrochemical devices, in particular in organic semiconductors. The complexes are further useful as over-discharge prevention and overvoltage protection agents.

  本发明涉及一种包含钴配合物的电化学器件，该配合物至少包含一种含有5或6个成员的N-含杂环配体。该配合物可用作p-和n-掺杂剂，用于电化学器件，特别是有机半导体中。此外，该配合物还可用作过放电防止和过电压保护剂。
• HISTONE DEMETHYLASE INHIBITORS
  申请人：Quanticel Pharmaceuticals, Inc.

  公开号：US20160113914A1

  公开（公告）日：2016-04-28

  The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本发明涉及治疗癌症和肿瘤疾病的组合物和方法。本文提供了取代咪唑-吡啶衍生物化合物和包含该化合物的药物组合物。该化合物和组合物可用于抑制组蛋白去甲基化酶酶。此外，该化合物和组合物可用于治疗癌症，例如前列腺癌，乳腺癌，膀胱癌，肺癌和/或黑色素瘤等。