methyl 2-(p-benzoylphenoxy)-2-methylpropionate | 42019-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-(p-benzoylphenoxy)-2-methylpropionate
• 英文别名: methyl 2-(4-benzoylphenoxy)-2-methylpropanoate
• CAS: 42019-11-4
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: ISYRGPPEWKMBAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(p-benzoylphenoxy)-2-methylpropionate 、 二乙氨基乙醇 在 titanium(IV) isopropylate 作用下， 生成 2-(4-Benzoyl-phenoxy)-2-methyl-propionic acid 2-diethylamino-ethyl ester
  参考文献：
  名称：

  FR2300552

  摘要：

  公开号：

文献信息

• Phenylmethylphenoxy propionic acid esters
  申请人：Orchimed S.A.

  公开号：US04072705A1

  公开（公告）日：1978-02-07

  Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.

  公式为##STR1##的化合物，其中A是较低的烷基，或取代或未取代的苯基，噻吩基，呋喃基，吲哚基或噻吲哚基，R，X.sub.4和X.sub.5为氢或较低的烷基，Y为氢，羟基，醚化羟基，取代氨基，或N-连接的杂环基，X.sub.0为O或OCH.sub.2 CH.sub.2 O，R'代表氢，较低的烷基或乙酰基；以及其酸加合盐，在药学中作为降脂、降胆固醇和促胆汁作用剂或用于制备此类剂的方面是新颖且有用的。
• Benzoylphenoxy propionic acid, esters thereof and pharmaceutical
  申请人：Orchimed S. A.

  公开号：US04179515A1

  公开（公告）日：1979-12-18

  Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholosterolaemiant and cholagogic agents or in the preparation of such agents.

  分子式为##STR1##的化合物中，A是较低的烷基，或取代或未取代的苯基，噻吩基，呋喃基，吲哚基或噻吲哚基基团，R，X4和X5为氢或较低的烷基，Y为氢，羟基，醚化羟基，取代氨基或N-附着的杂环基，X0为O或OCH2CH2O，R'代表氢，较低的烷基或乙酰基；以及它们的酸加成盐，在药学中作为降低血脂，降低胆固醇和胆汁排泄剂或制备这些剂的新型有用化合物。
• Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the
  申请人：Orchimed S.A.

  公开号：US04235896A1

  公开（公告）日：1980-11-25

  Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholosterolaemiant and cholagogic agents or in the preparation of such agents.

  式为##STR1##的化合物，其中A为低碳基或取代或未取代的苯基、噻吩基、呋喃基、吲哚基或噻吲哚基，R、X4和X5为氢或低碳基，Y为氢、羟基、醚化羟基、取代氨基或N-连接的杂环基，X0为O或OCH2CH2O，R'代表氢、低碳基或乙酰基；以及它们的酸加成盐，在药学中作为降血脂、降胆固醇和胆汁排泄剂或制备这些剂的有用新化合物。
• US4179515A
  申请人：——

  公开号：US4179515A

  公开（公告）日：1979-12-18
• US4235896A
  申请人：——

  公开号：US4235896A

  公开（公告）日：1980-11-25