3-bromo-2',6'-dimethyl-4'-propoxypropionanilide | 53985-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-bromo-2',6'-dimethyl-4'-propoxypropionanilide
• 英文别名: 3-bromo-N-(2,6-dimethyl-4-propoxyphenyl)propanamide
• CAS: 53985-06-1
• 化学式: C₁₄H₂₀BrNO₂
• 分子量: 314.222
• InChiKey: XSKLBAHERPZBTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-bromo-2',6'-dimethyl-4'-propoxypropionanilide 、 potassium phtalimide 以88%的产率得到
  参考文献：
  名称：

  TENTHOREY P. A.; DIRUBIO R. L.; FELDMAN H. S.; TAKMAN B. H.; BYRNES E. W.+, J. MED. CHEM., 1979, 22, NO 10, 1182-1186

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-Dimethyl-4-propoxyanilin 、 3-溴丙酰氯 以93%的产率得到
  参考文献：
  名称：

  TENTHOREY P. A.; DIRUBIO R. L.; FELDMAN H. S.; TAKMAN B. H.; BYRNES E. W.+, J. MED. CHEM., 1979, 22, NO 10, 1182-1186

  摘要：

  DOI：

文献信息

• Primary aminoacylanilides, methods of making the same and use as
  申请人：Astra Pharmaceutical Products, Inc.

  公开号：US04218477A1

  公开（公告）日：1980-08-19

  Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R.sub.8 can also be methyl; (b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl; (c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only; (d) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 are hydrogen, and n is 0, then R.sub.6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route.

  主要氨基酰基苯胺的结构式为##STR1##其中R.sub.1从氢、甲基、乙基和丙基中选择，R.sub.2从甲基、乙基、氯、甲氧基和乙氧基中选择，R.sub.3从氢和甲基中选择，R.sub.4从氢、甲基和C.sub.1 -C.sub.4烷氧基中选择，R.sub.6从甲基、乙基、氯、甲氧基和乙氧基中选择，R.sub.7为氢、甲基或乙基，R.sub.8为氢，R.sub.9为氢、甲基或乙基，R.sub.10为氢，n为0或1，具体规定如下：(a)当n为0时，R.sub.8也可以是甲基；(b)当n为1且R.sub.7为氢，R.sub.9为氢或甲基时，R.sub.10也可以是甲基；(c)当R.sub.1为氢，R.sub.2为甲基，R.sub.3为氢，R.sub.6为甲基，R.sub.7为氢，R.sub.8为氢，n为0时，R.sub.4只能是乙氧基或丙氧基；(d)当R.sub.1为氢，R.sub.2为甲基，R.sub.3、R.sub.4、R.sub.7和R.sub.8为氢，n为0时，R.sub.6只能是甲氧基、乙氧基或乙基；以及其治疗上可接受的盐。已发现这类化合物在口服给药时，特别是作为长效心脏抗心律失常药物，具有良好的疗效。
• Primary aminoacylanilides
  申请人：Astra Pharmaceutical Products, Inc.

  公开号：US04237068A1

  公开（公告）日：1980-12-02

  Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R.sub.8 can also be methyl; (b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl; (c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only; (d) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 are hydrogen, and n is 0, then R.sub.6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route.

  式子为##STR1##的一级氨基苯甲酰胺，其中R.sub.1选自氢、甲基、乙基和丙基组成的群体，R.sub.2选自甲基、乙基、氯、甲氧基和乙氧基组成的群体，R.sub.3选自氢和甲基组成的群体，R.sub.4选自氢、甲基和C.sub.1-C.sub.4烷氧基组成的群体，R.sub.6选自甲基、乙基、氯、甲氧基和乙氧基组成的群体，R.sub.7为氢、甲基或乙基，R.sub.8为氢，R.sub.9为氢、甲基或乙基，R.sub.10为氢，n为0或1，条件是（a）当n为0时，R.sub.8也可以是甲基；（b）当n为1，且R.sub.7为氢，R.sub.9为氢或甲基时，R.sub.10也可以是甲基；（c）当R.sub.1为氢，R.sub.2为甲基，R.sub.3为氢，R.sub.6为甲基，R.sub.7为氢，R.sub.8为氢，n为0时，R.sub.4只能是乙氧基或丙氧基；（d）当R.sub.1为氢，R.sub.2为甲基，R.sub.3、R.sub.4、R.sub.7和R.sub.8为氢，n为0时，R.sub.6只能是甲氧基、乙氧基或乙基；以及其治疗上可接受的盐。已发现此类化合物在口服时可以成为有效的长效心脏抗心律失常药物。
• US4218477A
  申请人：——

  公开号：US4218477A

  公开（公告）日：1980-08-19
• US4237068A
  申请人：——

  公开号：US4237068A

  公开（公告）日：1980-12-02
• TENTHOREY P. A.; DIRUBIO R. L.; FELDMAN H. S.; TAKMAN B. H.; BYRNES E. W.+, J. MED. CHEM., 1979, 22, NO 10, 1182-1186
  作者：TENTHOREY P. A.、 DIRUBIO R. L.、 FELDMAN H. S.、 TAKMAN B. H.、 BYRNES E. W.+

  DOI：——

  日期：——