N-(2-methoxyethyl)oxolane-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: N-(2-methoxyethyl)oxolane-2-carboxamide
• 化学式: C₈H₁₅NO₃
• 分子量: 173.21
• InChiKey: GVWPZNAKOGXEKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Sustained-release preparation
  申请人：Kamei Shigeru

  公开号：US20090048180A1

  公开（公告）日：2009-02-19

  A sustained-release preparation which comprises a physiologically active peptide of general formula wherein X represents an acyl group; R 1 , R 2 and R 4 each represents an aromatic cyclic group; R 3 represents a D-amino acid residue or a group of the formula wherein R 3 ′ is a heterocyclic group; R 5 represents a group of the formula —(CH 2 ) n —R 5 ′ wherein n is 2 or 3, and R 5 ′ is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group; R 6 represents a group of the formula —(CH 2 ) n —R 6 ′ wherein n is 2 or 3, and R 6 ′ is an amino group which may optionally be substituted; R 7 represents a D-amino acid residue or an azaglycyl residue; and Q represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group. The sustained-release preparation shows a constant release of the peptide over a long time and is substantially free from an initial burst.