(R)-1-phenyl-1-(3,5-dimethylphenyl)ethane | 1142813-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1-phenyl-1-(3,5-dimethylphenyl)ethane
• 英文别名: 1-phenyl-1-(3,5-dimethylphenyl)ethane；1,3-dimethyl-5-[(1R)-1-phenylethyl]benzene
• CAS: 1142813-43-1
• 化学式: C₁₆H₁₈
• 分子量: 210.319
• InChiKey: LVUFHDXEVLCSII-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1,3-二甲基-5-碘苯 、 4,4,5,5-四甲基-2-(1-苯基乙基)-1,3,2-二噁硼烷 在 四(三苯基膦)钯 、 potassium carbonate 、 三苯基膦 、 silver(l) oxide 作用下， 以 乙二醇二甲醚 为溶剂， 反应 24.0h， 生成 (R)-1-phenyl-1-(3,5-dimethylphenyl)ethane 、 (S)-1-phenyl-1-(3,5-dimethylphenyl)ethane
  参考文献：
  名称：

  Highly Chemoselective and Enantiospecific Suzuki-Miyaura Cross-Couplings of Benzylic Organoboronic Esters

  摘要：

  The use of potassium carbonate in addition to silver oxide is shown to increase the enantiospecificity of the Suzuki-Miyaura cross-coupling reaction of chiral secondary benzylic boronic esters. From mechanistic studies, it is shown that the reaction is compatible with Mizoroki-Heck coupling partners, even when they are present in considerable excess. This unique chemoselectivity provides the opportunity to carry out sequential reactions.

  DOI：

  10.1055/s-0033-1338875

文献信息

• Imao, Daisuke; Glasspoole, Ben W.; Laberge, Veronique S., Journal of the American Chemical Society, 2009, vol. 131, p. 5024 - 5025
  作者：Imao, Daisuke、Glasspoole, Ben W.、Laberge, Veronique S.、Crudden, Cathleen M.

  DOI：——

  日期：——
• Highly Chemoselective and Enantiospecific Suzuki-Miyaura Cross-Couplings of Benzylic Organoboronic Esters
  作者：Cathleen Crudden、Ben Glasspoole、Martins Oderinde、Brandon Moore、Aurora Antoft-Finch

  DOI：10.1055/s-0033-1338875

  日期：——

  The use of potassium carbonate in addition to silver oxide is shown to increase the enantiospecificity of the Suzuki-Miyaura cross-coupling reaction of chiral secondary benzylic boronic esters. From mechanistic studies, it is shown that the reaction is compatible with Mizoroki-Heck coupling partners, even when they are present in considerable excess. This unique chemoselectivity provides the opportunity to carry out sequential reactions.