1-(Azidomethyl)-4-dicyclohexylphosphorylbenzene | 1206518-79-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(Azidomethyl)-4-dicyclohexylphosphorylbenzene
• 英文别名: 1-(azidomethyl)-4-dicyclohexylphosphorylbenzene
• CAS: 1206518-79-7
• 化学式: C₁₉H₂₈N₃OP
• 分子量: 345.425
• InChiKey: NSSJLSBEKMCNLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(Azidomethyl)-4-dicyclohexylphosphorylbenzene 、 四(4-乙炔基苯)甲烷 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  “点击”树枝状膦：设计，合成，在铃木偶联中的应用以及纳米过滤的回收利用

  摘要：

  Abstractmagnified imageA new synthetic route towards stable molecular‐weight enlarged monodentate phosphine ligands via ‘click’ chemistry was developed. These ligands were applied in the Pd‐catalyzed Suzuki–Miyaura coupling of aryl halides and phenyl boronic acid. The supported systems show very similar activities compared to the unsupported analogues. Moreover, recycling experiments by means of nanofiltration using ceramic nanofiltration membranes demonstrate that these systems can be recovered and reused efficiently.

  DOI：

  10.1002/adsc.200900058
• 作为产物：
  描述：

  在 triflic azide 、 碳酸氢钠 、 copper(II) sulfate 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 反应 6.0h， 生成 1-(Azidomethyl)-4-dicyclohexylphosphorylbenzene
  参考文献：
  名称：

  “点击”树枝状膦：设计，合成，在铃木偶联中的应用以及纳米过滤的回收利用

  摘要：

  Abstractmagnified imageA new synthetic route towards stable molecular‐weight enlarged monodentate phosphine ligands via ‘click’ chemistry was developed. These ligands were applied in the Pd‐catalyzed Suzuki–Miyaura coupling of aryl halides and phenyl boronic acid. The supported systems show very similar activities compared to the unsupported analogues. Moreover, recycling experiments by means of nanofiltration using ceramic nanofiltration membranes demonstrate that these systems can be recovered and reused efficiently.

  DOI：

  10.1002/adsc.200900058

文献信息

• ‘Click’ Dendritic Phosphines: Design, Synthesis, Application in Suzuki Coupling, and Recycling by Nanofiltration
  作者：Michèle Janssen、Christian Müller、Dieter Vogt

  DOI：10.1002/adsc.200900058

  日期：2009.2

  Abstractmagnified imageA new synthetic route towards stable molecular‐weight enlarged monodentate phosphine ligands via ‘click’ chemistry was developed. These ligands were applied in the Pd‐catalyzed Suzuki–Miyaura coupling of aryl halides and phenyl boronic acid. The supported systems show very similar activities compared to the unsupported analogues. Moreover, recycling experiments by means of nanofiltration using ceramic nanofiltration membranes demonstrate that these systems can be recovered and reused efficiently.