N'-Acetyl-N-benzyl-hydrazinecarboxylic acid 4-nitro-phenyl ester | 17016-41-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-Acetyl-N-benzyl-hydrazinecarboxylic acid 4-nitro-phenyl ester
• 英文别名: (4-nitrophenyl) N-acetamido-N-benzylcarbamate
• CAS: 17016-41-0
• 化学式: C₁₆H₁₅N₃O₅
• 分子量: 329.312
• InChiKey: JWIWOOJFIQHSBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  101.78
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  对硝基苯基氯甲酸酯 、 1-acetyl-2-benzylhydrazine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N'-Acetyl-N-benzyl-hydrazinecarboxylic acid 4-nitro-phenyl ester
  参考文献：
  名称：

  An active-site titrant for chymotrypsin, and evidence that azapeptide esters are less susceptible to nucleophilic attack than ordinary esters

  摘要：

  The p-nitrophenyl ester of N-methoxycarbonylazaphenylalanine reacts with chymotrypsin in 1:1 stoichiometry, and the enzyme concentration can be quantified from the absorbance of the p-nitrophenolate produced in the reaction. This azapeptide does not decompose at pH 7 in the presence or absence of 1 mM hydroxylamine. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00308-3

文献信息

• An active-site titrant for chymotrypsin, and evidence that azapeptide esters are less susceptible to nucleophilic attack than ordinary esters
  作者：Jill M. Gassman、Joe Magrath

  DOI：10.1016/0960-894x(96)00308-3

  日期：1996.8

  The p-nitrophenyl ester of N-methoxycarbonylazaphenylalanine reacts with chymotrypsin in 1:1 stoichiometry, and the enzyme concentration can be quantified from the absorbance of the p-nitrophenolate produced in the reaction. This azapeptide does not decompose at pH 7 in the presence or absence of 1 mM hydroxylamine. Copyright (C) 1996 Elsevier Science Ltd