5-{[ethyl(4-methylphenyl)amino]methyl}-2(5H)-furanone | 1105066-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{[ethyl(4-methylphenyl)amino]methyl}-2(5H)-furanone
• 英文别名: 2-[(N-ethyl-4-methylanilino)methyl]-2H-furan-5-one
• CAS: 1105066-14-5
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: XEPUZBGDJLEJJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-ethyl-N,4-dimethylaniline 、 (furan-2-yloxy)triisopropylsilane 在 TBHP 、 copper(I) bromide 作用下， 以 甲醇 、 癸烷 为溶剂， 以67%的产率得到5-{[ethyl(4-methylphenyl)amino]methyl}-2(5H)-furanone
  参考文献：
  名称：

  Highly efficient Cu-catalyzed oxidative coupling of tertiary amines and siloxyfurans

  摘要：

  A mild, selective, and efficient protocol for the synthesis of gamma-aminoalkyl butenolides via the oxidative coupling between tertiary amines and siloxyfurans catalyzed by simple copper salts was developed. Compared with the reported method, our method employs copper catalyst instead of the expensive rhodium catalyst. Besides TBHP, both O-2 and H2O2 can also be utilized as oxidant to effect the coupling. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.078

文献信息

• Highly efficient Cu-catalyzed oxidative coupling of tertiary amines and siloxyfurans
  作者：Youming Shen、Ze Tan、De Chen、Xunbo Feng、Mo Li、Can-Cheng Guo、Chengliang Zhu

  DOI：10.1016/j.tet.2008.10.078

  日期：2009.1

  A mild, selective, and efficient protocol for the synthesis of gamma-aminoalkyl butenolides via the oxidative coupling between tertiary amines and siloxyfurans catalyzed by simple copper salts was developed. Compared with the reported method, our method employs copper catalyst instead of the expensive rhodium catalyst. Besides TBHP, both O-2 and H2O2 can also be utilized as oxidant to effect the coupling. (C) 2008 Elsevier Ltd. All rights reserved.