1-[Piperidin-1-ium-1-ylidene(piperidin-1-yl)methoxy]benzotriazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-[Piperidin-1-ium-1-ylidene(piperidin-1-yl)methoxy]benzotriazole
• 化学式: C17H24N5O+
• 分子量: 314.4
• InChiKey: DPXIXKZNWRNWIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Process for preparing a cross-linked carboxyl polysaccharide and the cross-linked carboxyl polysaccharide
  申请人：Young Jenn-Jong

  公开号：US20050281855A1

  公开（公告）日：2005-12-22

  A process for preparing a cross-linked polysaccharide comprises providing a polysaccharide with free carboxyl and hydroxyl groups capable of forming an intermolecular ester bond and cross-linking the polysaccharide by using onium salt, phosphonium salt, uronium salt or carbenium salt and in the presence or in the absence of organic base as cross-link reagent to obtain a highly cross-linked polysaccharide. The cross-linked polysaccharide has high cross-linking density and is stable and slowly biodegradable.

  制备交联多糖的方法包括提供具有能够形成分子间酯键的自由羧基和羟基的多糖，并使用盐酸盐、磷酸盐、尿酸盐或碳酸盐作为交联试剂，同时存在或不存在有机碱，以获得高度交联的多糖。这种交联多糖具有高交联密度，稳定且缓慢生物降解。
• METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES
  申请人：Toray Industries, Inc.

  公开号：EP3862431A1

  公开（公告）日：2021-08-11

  The present invention relates to a method for producing a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, comprising the step of reacting a first single-stranded oligo-RNA molecule represented by the following formula (I) with a second single-stranded oligo-RNA molecule represented by the following formula (II) in a mixed solvent comprising a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5'-Xc-Lx1 ... (I) and Lx2-X-Y-Ly-Yc-3' ... (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent comprising an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.

  本发明涉及一种生产能够抑制靶基因表达的发夹型单链 RNA 分子的方法，包括以下步骤： 在由缓冲溶液和亲水性有机溶剂组成的混合溶剂中，在脱水缩合剂存在的情况下，由下式 (I) 表示的第一单链寡核苷酸分子与由下式 (II) 表示的第二单链寡核苷酸分子反应： 5'-Xc-Lx1 ...... (I) 和 Lx2-X-Y-Ly-Yc-3' ...... (II) ，其中脱水缩合剂选自由三嗪类脱水缩合剂、脲类脱水缩合剂、脲类脱水缩合剂和脲类脱水缩合剂组成的组。...(I)和 Lx2-X-Y-Ly-Yc-3' ...(II)，其中脱水缩合剂选自由三嗪基脱水缩合剂、包含 N-羟基含氮芳香环结构的脲基脱水缩合剂、碳二亚胺基脱水缩合剂、2-卤代吡啶鎓基脱水缩合剂和甲脒基脱水缩合剂组成的组。
• NODULISPORIC ACID DERIVATIVES
  申请人：MERCK & CO., INC.

  公开号：EP0819000A1

  公开（公告）日：1998-01-21
• EP0819000A4
  申请人：——

  公开号：EP0819000A4

  公开（公告）日：2001-04-11
• SYNTHESIS OF 4- (Z)-(4-BROMOPHENYL)(ETHOXYIMINO)METHYL]-1'- 2,4-DIMETHYL-1-OXIDO-3-PYRIDINYL)CARBONYL]-4'METHYL-1,4'BIPIPERIDINE
  申请人：SCHERING CORPORATION

  公开号：EP1436284B1

  公开（公告）日：2005-08-03