benzyl N-[(2R)-nonan-2-yl]carbamate | 1011710-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl N-[(2R)-nonan-2-yl]carbamate
• CAS: 1011710-71-6
• 化学式: C₁₇H₂₇NO₂
• 分子量: 277.407
• InChiKey: BVGFNJUIUVGCFP-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-(+)-2-氨基壬烷 、 二苄基碳酸盐[脂] 在 sodium carbonate 作用下， 以 甲苯 为溶剂， 反应 72.0h， 生成 benzyl N-[(2R)-nonan-2-yl]carbamate 、
  参考文献：
  名称：

  Practical chemoenzymatic dynamic kinetic resolution of primary amines via transfer of a readily removable benzyloxycarbonyl group

  摘要：

  A practical method for chemoenzymatic dynamic kinetic resolution of primary amines using dibenzyl carbonate as acyl donor has been developed leading to benzyl carbamates, which can be deprotected under very mild reaction conditions to give the free amine. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.017

文献信息

• Practical chemoenzymatic dynamic kinetic resolution of primary amines via transfer of a readily removable benzyloxycarbonyl group
  作者：Christine E. Hoben、Lisa Kanupp、Jan-E. Bäckvall

  DOI：10.1016/j.tetlet.2007.12.017

  日期：2008.2

  A practical method for chemoenzymatic dynamic kinetic resolution of primary amines using dibenzyl carbonate as acyl donor has been developed leading to benzyl carbamates, which can be deprotected under very mild reaction conditions to give the free amine. (c) 2007 Elsevier Ltd. All rights reserved.