L-苯基丙氨酰-3,5-二碘-L-酪氨酸 | 80749-89-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: L-苯基丙氨酰-3,5-二碘-L-酪氨酸
• 英文名称: 1,3-Dioleoyl-2-(4-pyrenylbutanoyl)glycerol
• 英文别名: [3-[(Z)-octadec-9-enoyl]oxy-2-(4-pyren-1-ylbutanoyloxy)propyl] (Z)-octadec-9-enoate
• CAS: 80749-89-9
• 化学式: C₅₉H₈₆O₆
• 分子量: 891.3
• InChiKey: IGXQQAHHUHIOSW-CLFAGFIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  20.3
• 重原子数：
  65
• 可旋转键数：
  42
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Method of fluorometrically measuring the activity of fat-degrading enzymes and means for carrying out the method
  申请人：KSV-Chemicals Oy

  公开号：EP0037583A1

  公开（公告）日：1981-10-14

  The object of the present invention is a new method for fluorometrically assaying the activity of fat-degrading enzymes, such as lipases and phospholipases in samples containing said enzyme, such as in serum. According to the method the enzyme containing sample is reacted with a substrate containing acyl- or alkylglycerols or -phosphoglycerols having at least one fluorescent group, such as a pyrene group. The compounds may in addition contain fluorescence quenching groups. The enzyme hydrolyzes the substrate thus giving rise to changes in the fluorescence intensity during the enzyme reaction and the changes in the intensity are measured at a specific emission wavelength of the fluorescent group employed. The rate of change of the invensity is proportional to the enzyme activity in the sample. The invention concerns also the new compounds containing fluorescent groups to be used in the method.

  本发明的目的是一种用荧光测定含脂肪酶和磷脂酶的样品（如血清）中脂肪降解酶活性的新方法。根据该方法，含酶样品与含有至少一个荧光基团（如芘基）的酰基或烷基甘油或磷脂甘油的底物反应。此外，这些化合物还可能含有荧光淬灭基团。酶水解底物，从而在酶反应过程中引起荧光强度的变化，强度的变化是在所使用的荧光基团的特定发射波长下测量的。本发明的强度变化率与样品中的酶活性成正比。 本发明还涉及将用于该方法的含有荧光基团的新化合物。
• US4668623A
  申请人：——

  公开号：US4668623A

  公开（公告）日：1987-05-26