Dimethane sulfonate | 56967-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dimethane sulfonate
• 英文别名: 2-[4-formyl-3-methyl-N-(2-methylsulfonyloxyethyl)anilino]ethyl methanesulfonate
• CAS: 56967-08-9
• 化学式: C₁₄H₂₁NO₇S₂
• 分子量: 379.5
• InChiKey: CQVKMVQRSNNAGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-N,N-双(2-氯乙基)氨基-2-甲苯甲醛 生成 Dimethane sulfonate
  参考文献：
  名称：

  Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde

  摘要：

  本发明涉及使用某些二甲基亚砜化合物，如4-[双[2-[(甲基磺酰)氧基]乙基]氨基]-苯甲醛，治疗患有肾癌的哺乳动物。本发明还涉及治疗患有肾癌的患者的治疗方法的给药方案和剂量计划，以及适用于本文所提供的治疗方法的制药组合物。

  公开号：

  US07989501B2

文献信息

• Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde
  申请人：The United States of America as represented by the Secretary, Department of Health and Human Services

  公开号：US07989501B2

  公开（公告）日：2011-08-02

  The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.

  本发明涉及使用某些二甲基亚砜化合物，如4-[双[2-[(甲基磺酰)氧基]乙基]氨基]-苯甲醛，治疗患有肾癌的哺乳动物。本发明还涉及治疗患有肾癌的患者的治疗方法的给药方案和剂量计划，以及适用于本文所提供的治疗方法的制药组合物。
• JOC 1962, 27, 573-575
  申请人：——

  公开号：——

  公开（公告）日：——
• Treating or Preventing Renal Cancer Using a Dimethane Sulfonate
  申请人：Mertins Susan D.

  公开号：US20090131536A1

  公开（公告）日：2009-05-21

  The present invention features methods of treating renal cancer by administration of certain dimethylsulfonate compounds. The present invention further features administration protocols and dosing schedules for methods of treating patients suffering from renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
• TREATING RENAL CANCER USING A 4-[BIS[2-[(METHYLSULFONYL)OXY]ETHYL]AMINO]-2-METHYL-BENZALDEHYDE
  申请人：Mertins Susan D.

  公开号：US20110269840A1

  公开（公告）日：2011-11-03

  The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.
• US7989501B2
  申请人：——

  公开号：US7989501B2

  公开（公告）日：2011-08-02