3-dichloroacetyl-4-methyl-5-ethyl-2-n-propyl-1,3-oxazolidine | 1352572-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-dichloroacetyl-4-methyl-5-ethyl-2-n-propyl-1,3-oxazolidine
• 英文别名: 2,2-Dichloro-1-(5-ethyl-4-methyl-2-propyl-1,3-oxazolidin-3-yl)ethanone
• CAS: 1352572-31-6
• 化学式: C₁₁H₁₉Cl₂NO₂
• 分子量: 268.183
• InChiKey: SGQYQDCMMYCEKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-amine-3-pentanol 在 sodium hydroxide 作用下， 以 水 、 苯 为溶剂， 反应 0.5h， 生成 3-dichloroacetyl-4-methyl-5-ethyl-2-n-propyl-1,3-oxazolidine
  参考文献：
  名称：

  Microwave-Assisted Synthesis and Bioactivity of Novel 2,2,4,5-Tetrasubstituted 3-Dichloroacetyl-1,3-oxazolidines

  摘要：

  An efficient one-pot synthesis of 2,2,4,5-tetrasubstituted 3-dichloroacetyl-1,3-oxazolidines under microwave irradiation was developed. The intermediate oxazolidines were attained by the reaction of amino alcohol with aldehyde or ketone in refluxing benzene with microwave-assisted cycloaddition, and then the acylation followed with dichloroacetyl chloride and NaOH acting as the attaching acid agent. All the compounds were characterized by FR, H-1-NMR, C-13-NMR and elemental analysis. The preliminary biological test shows that these compounds could protect maize against injury caused by acetochlor to a certain extent.

  DOI：

  10.3987/com-11-12326