1-Chlor-2-oxo-3-(4-methylphenyl)propan | 24253-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Chlor-2-oxo-3-(4-methylphenyl)propan
• 英文别名: 1-Chlor-3-(4-methyl-phenyl)-propan-2-on；1-Chlor-3-(p-methylphenyl)-propanon；1-Chlor-3--propanon-(2)；1-chloro-3-p-tolyl-propan-2-one；1-Chloro-3-(4-methylphenyl)propan-2-one
• CAS: 24253-14-3
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: FKYIKCMAJJDPQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Chlor-2-oxo-3-(4-methylphenyl)propan 、 硫脲 以 乙醇 为溶剂， 生成 2-Amino-4-<4-methyl-benzyl>-thiazol
  参考文献：
  名称：

  Mahajanshetti,C.S.; Nargund,K.S., Journal of the Indian Chemical Society, 1962, vol. 39, p. 420 - 426

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 对甲苯乙酰氯 生成 1-Chlor-2-oxo-3-(4-methylphenyl)propan
  参考文献：
  名称：

  1-Halo-3-phenylpropan-2-ones from Diazoketones

  摘要：

  DOI：

  10.1055/s-1971-35040

文献信息

• 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors
  申请人：——

  公开号：US20040267017A1

  公开（公告）日：2004-12-30

  The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.

  本发明提供了一种带有3-吡啶基或4-异喹啉基取代基的新型噻唑，并提供了其制药组合物。本发明还提供了使用本发明化合物和制药组合物作为裂解酶抑制剂（例如17a-羟基酶-C17,20酶）的方法。本发明还提供了治疗患者癌症的方法，包括向患者投药本发明化合物或制药组合物。癌症可以是前列腺癌或乳腺癌等。
• 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1432706A2

  公开（公告）日：2004-06-30
• [EN] 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS<br/>[FR] THIAZOLES 3-PYRIDYLE OU 4-ISOQUINOLINYLE UTILISES COMME INHIBITEURS DE LYASE C17,20
  申请人：BAYER AG

  公开号：WO2003027085A2

  公开（公告）日：2003-04-03

  The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.
• [EN] NOVEL DERIVATIVES OF IMIDAZOLE, USE OF NOVEL DERIVATIVES OF IMIDAZOLE AND A METHOD OF MANUFACTURING THEM<br/>[FR] NOUVEAUX DÉRIVÉS D'IMIDAZOLE, UTILISATION DES NOUVEAUX DÉRIVÉS D'IMIDAZOLE ET PROCÉDÉ DE FABRICATION DE CES DERNIERS
  申请人：UNIV MEDYCZNY IM KAROLA MARCIN

  公开号：WO2009070045A2

  公开（公告）日：2009-06-04

  The subject of the present application are derivatives of imidazole, a method of manufacturing them as well as their use as active substance in medicinal products for use in human and veterinary medicine. The derivatives of imidazole according to the present invention are compounds with the general formula (1) in which R1, R2, R3 and n have the meanings as defined in the description.
• 1-Halo-3-phenylpropan-2-ones from Diazoketones
  作者：K. BREWSTER、R. M. PINDER

  DOI：10.1055/s-1971-35040

  日期：——