The present invention relates to a conjugate or its pharmaceutically acceptable salt, wherein said conjugate is water-insoluble and comprises a carrier moiety Z to which one or more moieties -L2-L1-D are conjugated, wherein each -L2- is individually a chemical bond or a spacer moiety; each -L1- is individually a linker moiety to which -D is reversibly and covalently conjugated; and each -D is individually a pattern recognition receptor agonist. It further relates to pharmaceutical compositions comprising such conjugate and to their use in the treatment of cell-proliferation disorders; and to related aspects.
本发明涉及一种缀合物或其药用可接受的盐,其中所述缀合物
水不溶,并包括一个载体部分Z,一个或多个部分-
L2-L1-D与所述载体部分Z缀合,其中每个-
L2-各自是一个
化学键或一个间隔部分;每个-L1-各自是一个连接部分,-D与所述连接部分可逆且共价地缀合;并且每个-D各自是一个模式识别受体激动剂。本发明还涉及包含这种缀合物的药物组合物,以及它们在治疗细胞增殖障碍疾病中的用途;和相关方面。