4,3'-dichloro-2-fluoro-3,2'-dimethoxybiphenyl | 1426539-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,3'-dichloro-2-fluoro-3,2'-dimethoxybiphenyl
• 英文别名: 1-Chloro-4-(3-chloro-2-methoxyphenyl)-3-fluoro-2-methoxybenzene；1-chloro-4-(3-chloro-2-methoxyphenyl)-3-fluoro-2-methoxybenzene
• CAS: 1426539-35-6
• 化学式: C₁₄H₁₁Cl₂FO₂
• 分子量: 301.145
• InChiKey: HMILUKNKHFQNQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-6-氟苯甲醚 在 正丁基锂 作用下， 以 乙二醇二甲醚 、 正己烷 为溶剂， 生成 4,3'-dichloro-2-fluoro-3,2'-dimethoxybiphenyl
  参考文献：
  名称：

  METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF

  摘要：

  公开了形成硼酸及其中间体的方法。该方法可以包括将1-氯-2-取代-3-氟苯起始物与烷基锂混合在第一反应器中形成反应混合物。1-氯-2-取代-3-氟苯起始物可以与烷基锂反应形成锂中间体。反应混合物可以连续转移至第二个反应器，并连续引入硼酸盐以形成硼酸酯。硼酸可以通过用水合氢氧化钾处理硼酸酯后酸化来形成。这些方法可以提供硼酸的连续形成，并可以减少处理过程中存在的反应中间体的数量以及循环时间。公开了形成硼酸的系统。

  公开号：

  US20130066115A1

文献信息

• US9145428B2
  申请人：——

  公开号：US9145428B2

  公开（公告）日：2015-09-29
• [EN] METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉS ET SYSTÈMES POUR FORMER DES ACIDES BORONIQUES ET PRODUITS INTERMÉDIAIRES DE CEUX-CI
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2013040479A1

  公开（公告）日：2013-03-21

  Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a l-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The l-chloro-2-substituted-3 -fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.
• METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF
  申请人：Emonds Mark V. M.

  公开号：US20130066115A1

  公开（公告）日：2013-03-14

  Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.

  公开了形成硼酸及其中间体的方法。该方法可以包括将1-氯-2-取代-3-氟苯起始物与烷基锂混合在第一反应器中形成反应混合物。1-氯-2-取代-3-氟苯起始物可以与烷基锂反应形成锂中间体。反应混合物可以连续转移至第二个反应器，并连续引入硼酸盐以形成硼酸酯。硼酸可以通过用水合氢氧化钾处理硼酸酯后酸化来形成。这些方法可以提供硼酸的连续形成，并可以减少处理过程中存在的反应中间体的数量以及循环时间。公开了形成硼酸的系统。