4-(Diacetoxymethyl)benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Diacetoxymethyl)benzoic acid
• 英文别名: 4-(diacetyloxymethyl)benzoic acid
• 化学式: C₁₂H₁₂O₆
• 分子量: 252.224
• InChiKey: BIAHQADISPVQIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(Diacetoxymethyl)benzoic acid 在 poly(amidoamine) dendrimer functionalized sulfonic acid 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以89%的产率得到对醛基苯甲酸
  参考文献：
  名称：

  Functionalized Poly(Amidoamine) Dendrimer as a Strong Ionic Brønsted Acid Organocatalyst for Protection/Deprotection of Aldehydes

  摘要：

  Poly(amidoamine) dendrimer (PAMAM) was successfully functionalized by chlorosulfonic acid to form an strong ionic acid catalyst. The resulting polymeric catalyst was shown to be an efficient catalyst for the synthesis of 1,1-diacetyl from aldehydes under free solvent conditions at room temperature. Also, the deprotection of the resulting aldehydes was investigated under catalytic conditions. The Hammett acidity function of catalyst showed that catalyst is a strong Bronsted acid. Due to the multi-functional nature of PAMAM, the catalyst has high loading level of acidic protons.

  DOI：

  10.1080/10426507.2013.855768
• 作为产物：
  描述：

  乙酸酐 、 对醛基苯甲酸 在 poly(amidoamine) dendrimer functionalized sulfonic acid 作用下， 以 neat (no solvent) 为溶剂， 反应 0.33h， 以94%的产率得到4-(Diacetoxymethyl)benzoic acid
  参考文献：
  名称：

  Functionalized Poly(Amidoamine) Dendrimer as a Strong Ionic Brønsted Acid Organocatalyst for Protection/Deprotection of Aldehydes

  摘要：

  Poly(amidoamine) dendrimer (PAMAM) was successfully functionalized by chlorosulfonic acid to form an strong ionic acid catalyst. The resulting polymeric catalyst was shown to be an efficient catalyst for the synthesis of 1,1-diacetyl from aldehydes under free solvent conditions at room temperature. Also, the deprotection of the resulting aldehydes was investigated under catalytic conditions. The Hammett acidity function of catalyst showed that catalyst is a strong Bronsted acid. Due to the multi-functional nature of PAMAM, the catalyst has high loading level of acidic protons.

  DOI：

  10.1080/10426507.2013.855768

文献信息

• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• [EN] SALTS OF PAROXETINE<br/>[FR] SELS DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000001692A1

  公开（公告）日：2000-01-13

  Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.