1-(2,3-dihydroxypropyl)cytosin | 68398-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2,3-dihydroxypropyl)cytosin
• 英文别名: 4-Amino-1-(2,3-dihydroxypropyl)pyrimidin-2-one
• CAS: 68398-49-2
• 化学式: C₇H₁₁N₃O₃
• 分子量: 185.183
• InChiKey: LTTDCEYZEHQDGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  99.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,3-dihydroxypropyl)cytosin 、 氯甲基膦酸二氯化物 、 sodium hydroxide 生成 disodium;4-amino-1-[3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one
  参考文献：
  名称：

  HOLY, ANTONIN;ROSENBERG, IVAN

  摘要：

  DOI：

文献信息

• Phosphonate Ester Derivatives and Methods of Synthesis Thereof
  申请人：Ware Roy W.

  公开号：US20120058976A1

  公开（公告）日：2012-03-08

  The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

  该披露描述了合成膦酸酯衍生物的方法。根据该披露的首选方法允许大规模制备高纯度的膦酸酯化合物。在一些实施例中，根据该披露的首选方法还允许在比以往用于制备这类化合物的方法更好的产率下制备膦酸酯衍生物，而无需使用色谱纯化方法。还披露了膦酸酯衍生物的形态形式。
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE<br/>[FR] COMPOSITIONS ET MÉTHODES PERMETTANT D'INHIBER L'EXPRESSION DU GÈNE ALAS1
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2017048843A1

  公开（公告）日：2017-03-23

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.

  该发明涉及针对ALAS1基因的双链核糖核酸(dsRNA)组合物，以及使用这种dsRNA组合物来改变(ALAS1)表达的方法（例如，抑制）。
• Monomeric diols, phosphate linked oligomers formed therefrom and processes for preparing
  申请人：——

  公开号：US20030065146A1

  公开（公告）日：2003-04-03

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，用于制备寡聚体结构。乙二醇单体可以通过标准的磷酸酯和磷酸硫酯键连接。有用的功能基团包括核苷碱以及极性基团，疏水基团，离子基团，芳香基团和/或参与氢键的基团。
• Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 9, p. 2470 - 2501
  作者：Holy, Antonin、Rosenberg, Ivan、Dvorakova, Hana

  DOI：——

  日期：——
• NOVEL PROCESS FOR THE PREPARATION OF NUCLEOTIDES
  申请人：Bristol-Myers Squibb Company

  公开号：EP0574386A1

  公开（公告）日：1993-12-22