allyl 2-phenyl-2-(phenylsulfonyl)propanoate | 1067227-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: allyl 2-phenyl-2-(phenylsulfonyl)propanoate
• 英文别名: Prop-2-enyl 2-(benzenesulfonyl)-2-phenylpropanoate
• CAS: 1067227-34-2
• 化学式: C₁₈H₁₈O₄S
• 分子量: 330.405
• InChiKey: ZZHJHYRJHJTMDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  allyl 2-phenyl-2-(phenylsulfonyl)propanoate 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 0.17h， 以95%的产率得到(2-phenylpent-4-en-2-ylsulfonyl)benzene
  参考文献：
  名称：

  Decarboxylative Allylation using Sulfones as Surrogates of Alkanes

  摘要：

  alpha-Sulfonyl functional groups are traceless activating groups that facilitate catalytic decarboxylative allylations in high yield yet can be cleaved to allow the synthesis of simple allylated alkanes. Substrate studies suggest that decarboxylation to form an a-sulfonyl anion is rate-limiting. Furthermore, the anion is formed reglospecifically under formally neutral conditions.

  DOI：

  10.1021/ol801951e
• 作为产物：
  描述：

  烯丙醇 、 α-benzenesulfonyl-α-phenylpropionic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 生成 allyl 2-phenyl-2-(phenylsulfonyl)propanoate
  参考文献：
  名称：

  Decarboxylative Allylation using Sulfones as Surrogates of Alkanes

  摘要：

  alpha-Sulfonyl functional groups are traceless activating groups that facilitate catalytic decarboxylative allylations in high yield yet can be cleaved to allow the synthesis of simple allylated alkanes. Substrate studies suggest that decarboxylation to form an a-sulfonyl anion is rate-limiting. Furthermore, the anion is formed reglospecifically under formally neutral conditions.

  DOI：

  10.1021/ol801951e

文献信息

• Decarboxylative Allylation using Sulfones as Surrogates of Alkanes
  作者：Jimmie D. Weaver、Jon A. Tunge

  DOI：10.1021/ol801951e

  日期：2008.10.16

  alpha-Sulfonyl functional groups are traceless activating groups that facilitate catalytic decarboxylative allylations in high yield yet can be cleaved to allow the synthesis of simple allylated alkanes. Substrate studies suggest that decarboxylation to form an a-sulfonyl anion is rate-limiting. Furthermore, the anion is formed reglospecifically under formally neutral conditions.