N,N,N',N'-四甲基-2,2-二甲基-1,3-丙二胺 | 53369-79-2

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N,N',N'-四甲基-2,2-二甲基-1,3-丙二胺
• 中文别名: N,N,N',N',2,2-六甲基-1,3-丙二胺；N,N,N’,N’-四甲基-2,2-二甲基-1,3-丙二胺；N,N,N',N'-四甲基-1,3-二氨基-2,2-二甲基丙烷
• 英文名称: N,N,N',N',2,2-Hexamethyl-1,3-propandiamin
• 英文别名: N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-propanediamine；N,N,N',N',2,2-hexamethylpropane-1,3-diamine
• CAS: 53369-79-2
• 化学式: C₉H₂₂N₂
• mdl: MFCD00053430
• 分子量: 158.287
• InChiKey: MOBAUGYLXJCSAW-UHFFFAOYSA-N

物化性质

• 沸点：
  162 °C
• 密度：
  0.80
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  8/3
• 海关编码：
  2921290000
• 包装等级：
  II
• 危险类别：
  3,8
• 危险性防范说明：
  P210,P233,P240,P241+P242+P243,P260,P264,P280,P301+P330+P331+P310,P303+P361+P353+P310+P363,P304+P340+P310,P305+P351+P338+P310,P370+P378,P403+P235,P405,P501
• 危险品运输编号：
  2733
• 危险性描述：
  H226,H314
• 储存条件：
  请将贮藏器密封保存，并存放在阴凉干燥处。同时，确保工作环境具备良好的通风或排气设施。

SDS

N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-propanediamine Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-propanediamine

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS
Category 3
Flammable liquids
HEALTH HAZARDS
Category 1B
Skin corrosion/irritation
Serious eye damage/eye irritation Category 1
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Danger
Hazard statements Flammable liquid and vapour
Causes severe skin burns and eye damage
Precautionary statements:
[Prevention] Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Do not breathe dust/fume/gas/mist/vapours/spray.
Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
[Response]
breathing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
Wash contaminated clothing before reuse.
Immediately call a POISON CENTER or doctor/physician.
[Storage] Store in a well-ventilated place. Keep cool.
Store locked up.
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government.
N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-
propanediamine

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-propanediamine
Percent: >90.0%(GC)
CAS Number: 53369-79-2
Synonyms: N,N,N',N',2,2-Hexamethyl-1,3-propanediamine , N,N,N',N'-Tetramethyl-1,3-diamino-
2,2-dimethylpropane , N,N,N',N'-Tetramethylneopentanediamine
Chemical Formula: C9H22N2

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. Immediately call a POISON CENTER or doctor/physician.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.Immediately call a POISON CENTER or
doctor/physician.
Ingestion: Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT
induce vomiting.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, carbon dioxide.
media:
Unsuitable extinguishing Water (It may scatter and spread fire.)
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use extra personal protective equipment (self-contained breathing apparatus). Keep
protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non-
emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-
propanediamine

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Section 7. HANDLING AND STORAGE
Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Store under inert gas.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Air-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied
air respirator, etc. Use respirators approved under appropriate government standards
and follow local and national regulations.
Impervious gloves.
Hand protection:
Eye protection: Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colorless - Very pale yellow
Colour:
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
162°C
Boiling point/range:
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 0.80
Solubility(ies):
No data available
[Water]
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Conditions to avoid: Spark, Open flame, Static discharge
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

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Section 11. TOXICOLOGICAL INFORMATION
No data available
Acute Toxicity:
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
N,N,N',N'-Tetramethyl-2,2-dimethyl-1,3-
propanediamine

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Section 11. TOXICOLOGICAL INFORMATION
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: 8: Corrosive.
3: Flammable liquid.
Subsidiary risk:
UN-No: 2734
Amines, liquid, corrosive, flammable, n.o.s.
Proper shipping name:
Packing group: II

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-四甲基-2,2-二甲基-1,3-丙二胺 、 zinc(II) chloride 以 乙醚 、 乙醇 为溶剂， 以>99的产率得到
  参考文献：
  名称：

  2,2-双（二甲基氨基甲基）丙烷的卤化锌配合物和1,1,1-三（二甲基氨基甲基）乙烷的卤化锌配合物的立体选择构象特征的身份

  摘要：

  摘要通过与新型“模型”配合物BTNZnX 2的比较研究，研究了由1,1,1-三（二甲基氨基甲基）乙烷（TTN）与卤化锌（ZnX 2）配位产生的冷冻TTNZnX 2构象异构体的鉴定。 ，其中BTN [2,2-双（二甲基氨基甲基）丙烷]是TTN的双齿类似物。BTNZnX 2配合物的特征是四配位的锌原子和六元螯合环。由于该环被对称地取代，因此与刚性TTNZnX 2系统相反，BTNZnX 2分子在室温下以两个不可区分的快速相互转换的伪椅子构象异构体以1：1的比例存在。后者立体选择性地作为AE构象体存在，其中C（5）甲基是轴向的，而C（5）二甲基氨基甲基是赤道的。该非对映异构体是特别优选的，这是由于庞大的C（5）二甲基氨基甲基的空间控制。TTNZnX 2构象异构体的成功鉴定是螯合物环的伪环己烷性质的结果，其中ZnX 2部分表现为理想的类金属，并允许环取代基的1 H NMR数据与方向相关。相关性在数量上与结构相似的有机化合物的相关性一致。

  DOI：

  10.1016/s0277-5387(00)83482-8
• 作为产物：
  描述：

  聚合甲醛 、 N,N,2,2-四甲基-1,3-丙二胺 生成 N,N,N',N'-四甲基-2,2-二甲基-1,3-丙二胺
  参考文献：
  名称：

  Synthesis of some cis- and trans-2-dimethylaminomethyl cyclic amines and related diamines

  摘要：

  DOI：

  10.1021/jo00891a005

文献信息

• (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD

  公开号：US20180118658A1

  公开（公告）日：2018-05-03

  The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.

  本发明提供了一种（甲基）丙烯酸酯制备方法，其特征在于通过在使用催化剂A和催化剂B一起进行醇和单官能基（甲基）丙烯酸酯之间的酯交换反应制备（甲基）丙烯酸酯时，对酯交换反应产物进行与吸附剂C的接触处理。催化剂A：从含有氮杂双环结构的环状三级胺及其盐或络合物、胺嘧啶及其盐或络合物、含有吡啶环的化合物及其盐或络合物、膦及其盐或络合物、以及含有三级二胺结构的化合物及其盐或络合物中选择的一种或多种化合物。催化剂B：从含锌化合物中选择的一种或多种化合物。吸附剂C：从含有镁、铝和硅中至少一种的氧化物和氢氧化物中选择的一种或多种化合物。
• Preparation of (chloromethyl)palladium(II) derivatives from complexes of palladium dichloride by reaction with diazomethane or bis(chloromethyl)mercury
  作者：Robert McCrindle、Gilles J. Arsenault、Rajeev Farwaha、Alan J. McAlees、David W. Sneddon

  DOI：10.1039/dt9890000761

  日期：——

  showed at least some tendency to revert to the starting dichloro complexes by loss of the methylene moiety. Products of insertion into a Pd–Br bond are less readily formed than those of the corresponding chloride and the resulting bromomethyl derivatives are less stable than their chloromethyl analogues. Chloromethyl derivatives were also prepared from the dichloride by treatment with bis(chloromethyl)mercury

  已经研究了用重氮甲烷处理一系列含有螯合配体的二氯化钯和二溴化物配合物。除了一个以外，都观察到单（卤代甲基）产物的形成。如果存在至少一种烯烃或膦配体，则来自二氯化钯配合物的亚甲基插入产物是相对稳定的，但是对于双胺或-硫化物配体，则不能分离出插入产物。但是，所有插入产物都显示出至少一些趋势，即由于亚甲基部分的损失而还原为起始的二氯配合物。插入到Pd-Br键中的产物比相应的氯化物更不易形成，并且生成的溴甲基衍生物的稳定性不如氯甲基类似物。
• Encapsulation of Protonated Diamines in a Water-Soluble, Chiral, Supramolecular Assembly Allows for Measurement of Hydrogen-Bond Breaking Followed by Nitrogen Inversion/Rotation
  作者：Michael D. Pluth、Robert G. Bergman、Kenneth N. Raymond

  DOI：10.1021/ja076691h

  日期：2008.5.1

  Amine nitrogen inversion, difficult to observe in aqueous solution, is followed in a chiral, supramolecular host molecule with purely rotational T-symmetry that reduces the local symmetry of encapsulated monoprotonated diamines and enables the observation and quantification of Delta G (++) for the combined hydrogen-bond breaking and nitrogen inversion/rotation (NIR) process. Free energies of activation

  在水溶液中很难观察到胺氮反转，随后是手性超分子主体分子，具有纯旋转 T 对称性，降低了封装的单质子化二胺的局部对称性，并能够观察和量化 Delta G (++)结合氢键断裂和氮反转/旋转（NIR）过程。手性组件内部氢键断裂和 NIR 过程的组合活化自由能通过 NMR 聚结法确定。用于从组件中喷射质子化胺的激活参数证实，负责聚结行为的 NIR 过程发生在组件内部，而不是通过客体喷射/NIR/重新封装机制。对于二胺之一，N，N，N'，N'-四甲基乙二胺，
• LIGAND EXCHANGE THERMOCHROMIC SYSTEMS AND HIGH E LIGANDS FOR SAME
  申请人：Byker J. Harlan

  公开号：US20080105851A1

  公开（公告）日：2008-05-08

  Ligand exchange of thermochromic, LETC, systems exhibiting a reversible change in absorbance of electromagnetic radiation as the temperature of the system is reversibly changed are described. The described LETC systems include one or more than one transition metal ion, which experiences thermally induced changes in the nature of the complexation or coordination around the transition metal ion(s) and, thereby, the system changes its ability to absorb electromagnetic radiation as the temperature changes. In accordance with certain aspects of the present invention, a thermochromic system is disclosed comprising a transition metal ion and a ligand wherein the ligand comprises a nitrogen-containing five or six membered heterocyclic compound that coordinates through the nitrogen atom to the transition metal ion in a HεMLC formed between the transition metal ion and the ligand. In accordance with other aspects of the present invention, thermochromic systems are disclosed comprising a transition metal ion with particularly useful ligands, such as phosphine compounds, tridentate ligands that coordinate through three nitrogen atoms, bidentate ligands, or ortho hindered pyridine monodentate ligands.

  本文描述了具有热致变色性质的配体交换（LETC）系统，当系统的温度可逆变化时，电磁辐射吸收率也可逆变化。所述的LETC系统包括一个或多个过渡金属离子，其经历热诱导的配位或配位环境的变化，从而使系统随着温度变化而改变吸收电磁辐射的能力。根据本发明的某些方面，公开了包括过渡金属离子和配体的热致变色系统，其中配体包括通过氮原子与过渡金属离子形成的HεMLC（配体与过渡金属离子之间的配位键）的含氮五元或六元杂环化合物。根据本发明的其他方面，公开了包括具有特别有用的配体的过渡金属离子的热致变色系统，例如膦化合物、通过三个氮原子配位的三齿配体、双齿配体或邻位受阻的吡啶单齿配体。
• LIGAND EXCHANGE THERMOCHROMIC SYSTEMS CONTAINING EXCHANGE METALS
  申请人：Byker J. Harlan

  公开号：US20080106781A1

  公开（公告）日：2008-05-08

  Ligand exchange of thermochromic, LETC, systems exhibiting a reversible change in absorbance of electromagnetic radiation as the temperature of the system is reversibly changed are described. The described LETC systems include one or more than one transition metal ion, which experiences thermally induced changes in the nature of the complexation or coordination around the transition metal ion(s) and, thereby, the system changes its ability to absorb electromagnetic radiation as the temperature changes. In accordance with one aspect of the present invention, a thermochromic system is disclosed comprising a first metal ion and a second metal ion and at least one ligand that complexes with the first metal ion to form a LεMLC and complexes with the second metal ion to form a HεMLC wherein an increase in temperature of the system results in a reversible net increase in its ability to absorb light energy in the 400 nm to 1400 nm range due to the ligand transferring from the first metal ion to the second metal ion.

  本文介绍了一种具有热致变色特性的配体交换系统，当系统的温度可逆变化时，其吸收电磁辐射的能力也可逆变化。所述的LETC系统包括一个或多个过渡金属离子，其在过渡金属离子周围的络合或配位发生热诱导变化，从而使系统随着温度变化而改变吸收电磁辐射的能力。根据本发明的一个方面，公开了一种热致变色系统，包括第一金属离子和第二金属离子以及至少一个配体，该配体与第一金属离子形成LεMLC配合物，并与第二金属离子形成HεMLC配合物，系统温度的升高导致可逆的净吸收光能力增加，范围为400纳米至1400纳米，这是由于配体从第一金属离子转移到第二金属离子造成的。