6-Chloro-2-(2-diethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6-Chloro-2-(2-diethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione
• 英文别名: 6-Chloro-2-[2-(diethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
• 化学式: C₁₈H₁₉ClN₂O₂
• 分子量: 330.814
• InChiKey: UJUWNQLOUDYZLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-氨基乙基)吗啉 、 6-Chloro-2-(2-diethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione 生成 2-(2-Diethylamino-ethyl)-6-(2-morpholin-4-yl-ethylamino)-benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Silva, A. Prasanna de; Rice, Terence E., Chemical Communications, 1999, # 2, p. 163 - 164

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯萘二甲酰亚胺 、 N,N-二乙基乙二胺 以 甲苯 为溶剂， 反应 4.0h， 以60%的产率得到6-Chloro-2-(2-diethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Arenedicarboximide Building Blocks for Fluorescent Photoinduced Electron Transfer pH Sensors Applicable with Different Media and Communication Wavelengths

  摘要：

  N-(aminoalkyl)-4-chloronaphthalene-1,8-dicarboximides 1, N-(aminoalkyl)-4-acetamidonaphthalene- 1,8-dicarboximides 3 and N,N'-bis(aminoalkyl)-perylene-3,4:9,10-tetracarboxydiimides 4 show good fluorescent off-on switching in aqueous alcoholic solution with protons as required for fluorescent PET sensor design. The excitation wavelengths lie in the ultraviolet (lambda(max) = 345 and 351 nm) for 1 and 3 and in the blue-green (lambda(max) = 528, 492 and 461 nm) for 4: the emission wavelengths lie in the violet (lambda(max) = 405 nm) for 1, in the blue (lambda(max) = 474 nm) for 3 and in the yellow-orange (lambda(max) = 543 and 583 nm) for 4. Compound 4b shows substantial fluorescence enhancement with protons when immobilized in a poly(vinylchloride) matrix, provided that 2-nitrophenyloctyl ether plasticizer and potassium tetrakis(4-chlorophenyl)borate additive are present to prevent dye crystalization and to facilitate proton diffusion into the membrane, respectively.

  DOI：

  10.1002/(sici)1521-3765(19980904)4:9<1810::aid-chem1810>3.0.co;2-y