A Mild Approach to the Synthesis of 4-Amino-8-(arylamino)pyrimido[5,4-d]pyrimidine 3-Oxides
作者:Alexandra Ribeiro、M. Alice Carvalho、M. Fernanda Proença
DOI:10.1002/ejoc.200900216
日期:2009.10
The reaction of benzylhydroxylamine with 6-cyanopurines leads to the formation of 7-benzyloxy-8-imino-7,8-dihydropyrimido[5,4-d]pyrimidines. The hydrochloride of these compounds, isolated upon addition of aqueous hydrochloric acid, is a convenient precursor of the pyrimido[5,4-d]pyrimidine N-oxides when a suspension of the salt is refluxed in ethanol or acetonitrile. Refluxing a solution of the same