dithiosalicylic acid | 1074-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dithiosalicylic acid
• 英文别名: 2-sulfanylbenzenecarbothioic S-acid
• CAS: 1074-01-7
• 化学式: C₇H₆OS₂
• 分子量: 170.256
• InChiKey: ORPKTFIMGFBJJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  19.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dithiosalicylic acid 在 lithium aluminium tetrahydride 、 铜 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成 4-(2-Hydroxymethyl-phenylsulfanyl)-N,N-dimethyl-benzenesulfonamide
  参考文献：
  名称：

  Pelz,K. et al., Collection of Czechoslovak Chemical Communications, 1968, vol. 33, # 6, p. 1895 - 1910

  摘要：

  DOI：
• 作为产物：
  描述：

  9-苯基-8-氧杂-10-硫杂双环[4.4.0]癸-1,3,5-三烯-7-酮 、 sodium thiophenolate 以 苯 为溶剂， 反应 9.0h， 以49%的产率得到bis(2-thiolocarbophenoxyphenyl) disulphide
  参考文献：
  名称：

  El-Barbary, A. A.; Hammouda, H. A.; El-Borai, M., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 8, p. 770 - 773

  摘要：

  DOI：

文献信息

• Method of producing an amide
  申请人：Williams Joseph Lawrence

  公开号：US20050215819A1

  公开（公告）日：2005-09-29

  The present invention discloses a new method for synthesizing an amide based on a fundamental mechanistic revision of the reaction of thio acids and organic azides. Moreover, the application of this method to the selective preparation of several classes of complex amides in nonpolar and polar solvents, including water, is provided.

  本发明揭示了一种基于对硫酸和有机叠氮化合物反应机理的根本修订的新的合成酰胺的方法。此外，提供了将该方法应用于在非极性和极性溶剂（包括水）中选择性制备多类复杂酰胺的方法。
• [EN] CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS<br/>[FR] COMPOSÉS DI-NUCLÉOTIDIQUES CYCLIQUES UTILISÉS EN TANT QU'AGONISTES DE STING
  申请人：MERCK SHARP & DOHME

  公开号：WO2020117625A1

  公开（公告）日：2020-06-11

  A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. (I)

  提供一类多环化合物，其一般式为（I），其中Base1、Base2、Y、Ya、Xa、Xa1、Xb、Xb1、Xc、Xc1、Xd、Xd1、R1、R1a、R2a、R3、R3a、R4、R4a、R5、R6、R6a、R7、R7a、R8、R8a和R9在此处定义，可能有用作I型干扰素产生的诱导剂，特别是作为STING活性剂。还提供了合成和使用化合物的方法。（I）
• [EN] 2-SUBSTITUTED BICYCLIC BENZOHETEROCYCLIC COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS<br/>[FR] COMPOSES BENZOHETEROCYCLIQUES BICYCLIQUES SUBSTITUES EN 2 ET LEUR UTILISATION EN TANT QUE BLOQUEURS DU CANAL SODIQUE
  申请人：EURO CELTIQUE SA

  公开号：WO2004013111A1

  公开（公告）日：2004-02-12

  This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel 2-substituted bicyclic benzoheterocyclic compounds of Formula I, or a pharmaceutically-acceptable salt or solvate thereof, wherein X is -NH-, -N= or -S-, Y is oxygen or sulfur, and n, p, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及一种治疗对钠离子通道阻滞具有反应的疾病的方法，使用新型的2-取代的双环苯杂环化合物，其化学式为I，或其药学上可接受的盐或溶剂，其中X为-NH-，-N=或-S-，Y为氧或硫，n，p，R1，R2，R3和R4在规范中有定义。该发明还涉及化合物I用于治疗全球性或局部性缺血后的神经损伤，用于治疗或预防神经退行性疾病，如肌萎缩侧索硬化症（ALS），以及用于治疗、预防或改善急性或慢性疼痛、神经病性疼痛或手术疼痛，作为抗耳鸣剂，抗癫痫药，抗躁狂抑郁药，局部麻醉剂，抗心律失常药以及治疗或预防糖尿病性神经病变。
• 3H-1,2-benzothiaselenol-3-one. A new selenizing reagent for nucleoside H-phosphonate and H-phosphonothioate diesters
  作者：Jacek Stawiński、Mats Thelin

  DOI：10.1016/s0040-4039(00)60887-0

  日期：1992.11

  A new selenium-transferring reagent, 3H-1,2-benzothiaselenol-3-one (1), has been developed for the conversion of nucleoside H-phosphonate and nucleoside H-phosphonothioate diesters into the corresponding seleno analogues. The reagent is soluble in common organic solvents and shows an enhanced rate of selenium transfer compared to elemental selenium or potassium selenocyanate. Selenization with the

  已经开发了一种新的硒转移试剂3 H -1,2-苯并硫代噻吩酚-3-酮（1），用于将核苷H-膦酸酯和核苷H-膦硫代酸酯二酯转化为相应的硒类似物。该试剂可溶于常见的有机溶剂，与元素硒或硒氰酸钾相比，硒的转移速率更高。试剂1的硒化是立体定向的，最有可能在磷中心保留构型而发生。
• 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers
  申请人：Euro-Celtique S.A.

  公开号：US20040152696A1

  公开（公告）日：2004-08-05

  This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel 2-substituted bicyclic benzoheterocyclic compounds of Formula I: 1 or a pharmaceutically-acceptable salt or solvate thereof, wherein X is —NH—, —N═ or —S—, Y is oxygen or sulfur, and n, p, R 1 , R 2 , R 3 and R 4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及使用新型2-取代双环苯并杂环化合物（公式I：1）或其药学上可接受的盐或溶剂，通过阻断钠离子通道来治疗对其敏感的疾病。其中，X为—NH—、—N═或—S—，Y为氧或硫，n、p、R1、R2、R3和R4在说明书中有定义。本发明还涉及使用公式I化合物治疗全局或局部缺血后的神经损伤，治疗或预防神经退行性疾病如肌萎缩性侧索硬化（ALS），以及治疗、预防或缓解急性或慢性疼痛、神经病理性疼痛或手术疼痛，作为抗耳鸣剂、抗癫痫药物和抗躁狂抑郁药物，作为局部麻醉剂、抗心律失常药物以及治疗或预防糖尿病神经病变的药物。