1-(3,4-dichloro-benzoyl)-4-methyl-piperazine | 33754-52-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-dichloro-benzoyl)-4-methyl-piperazine
• 英文别名: (3,4-dichlorophenyl)-(4-methylpiperazin-1-yl)methanone
• CAS: 33754-52-8
• 化学式: C₁₂H₁₄Cl₂N₂O
• mdl: MFCD01215609
• 分子量: 273.162
• InChiKey: GBJYMHJHFSYALJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌嗪 、 3,4-二氯苯甲酰氯 、 碘甲烷 以52%的产率得到1-(3,4-dichloro-benzoyl)-4-methyl-piperazine
  参考文献：
  名称：

  A novel traceless solid phase tertiary amine synthesis based on Merrifield resin

  摘要：

  Substitution of Merrifield resin by a secondary amine gives a resin-bound tertiary amine which is then quaternised with an alkyl halide to provide a resin-bound quaternary ammonium salt. Cleavage of the ammonium salt with morpholine delivers a tertiary amine ill high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02251-6

文献信息

• N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20100035879A1

  公开（公告）日：2010-02-11

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物是凋亡促进剂。还公开了制备这些化合物的方法、含有这些化合物的组合物以及使用这些化合物的治疗方法。
• N-SULFONYLUREA APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20080146572A1

  公开（公告）日：2008-06-19

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有以下化学式的化合物是凋亡促进剂。还公开了制备这些化合物的方法，含有这些化合物的组合物以及使用这些化合物进行治疗的方法。
• US7358251B2
  申请人：——

  公开号：US7358251B2

  公开（公告）日：2008-04-15
• A novel traceless solid phase tertiary amine synthesis based on Merrifield resin
  作者：Jiaqiang Cai、Bernard Wathey

  DOI：10.1016/s0040-4039(00)02251-6

  日期：2001.2

  Substitution of Merrifield resin by a secondary amine gives a resin-bound tertiary amine which is then quaternised with an alkyl halide to provide a resin-bound quaternary ammonium salt. Cleavage of the ammonium salt with morpholine delivers a tertiary amine ill high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.