(RS)-<4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl>bis(diphenylphosphine) | 91548-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RS)-<4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl>bis(diphenylphosphine)
• 英文别名: (RS)-{4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl}bis(diphenylphosphine)；(S)-(4,4'-bis(dimethylamino)-6,6'-dimethyl-2,2'-biphenylylene)-bis(diphenylphosphine)；4-[4-(dimethylamino)-2-diphenylphosphanyl-6-methylphenyl]-3-diphenylphosphanyl-N,N,5-trimethylaniline
• CAS: 91548-12-8
• 化学式: C₄₂H₄₂N₂P₂
• 分子量: 636.756
• InChiKey: NGPJMZBMZXQOTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (RS)-<4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl>bis(diphenylphosphine) 、 [RhCl(COD)]2 以76%的产率得到
  参考文献：
  名称：

  SCHMID, RUDOLF;CEREGHETTI, MARCO;HELSER, BERND;SCHONHOLZER, PETER;HANSEN,+, HELV. CHIM. ACTA, 71,(1988) N 4, 897-929

  摘要：

  DOI：
• 作为产物：
  描述：

  ((R)-2-{1-(dimethylamino)ethyl}phenyl-C,N){(R)-(4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine)}palladium(II) tetrafluoroborate 在 LiAlH₄ 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到(RS)-<4,4'-bis(dimethylamino)-6,6'-dimethylbiphenyl-2,2'-diyl>bis(diphenylphosphine)
  参考文献：
  名称：

  Schmid, Rudolf; Cereghetti, Marco; Heiser, Bernd, Helvetica Chimica Acta, 1988, vol. 71, p. 897 - 929

  摘要：

  DOI：

文献信息

• Axially Asymmetric Phosphorus Compound and Production Method Thereof
  申请人：Tanaka Ken

  公开号：US20090227805A1

  公开（公告）日：2009-09-10

  Problem to be Solved: To provide an axially asymmetric optically active biarylphosphorus compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. Solution: A method for producing an axially asymmetric phosphorus compound represented by the general formula (1), comprising a cycloaddition reaction of a compound having a triple bond with the use of a catalyst containing rhodium metal and an optically active bisphosphine. (In the formula, J is an oxygen atom, a sulfur atom or BH 3 ; R 1 and R 2 independently are an alkyl, cycloalkyl, aryl, alkoxy and aryloxy group; a1 and a2 independently are 0 or 1; R 3 to R 10 independently are an alkyl, cycloalkyl, aryl, alkoxy and aryloxy group; two among R 3 to R 10 may form a ring; and * is axial asymmetry.)

  要解决的问题：提供一种轴向不对称的光学活性联苯磷化合物，可以在传统方法中几乎不可或缺的光学分辨步骤之外轻松生产。 解决方案：一种生产由通式（1）表示的轴向不对称磷化合物的方法，包括使用含有铑金属和光学活性双膦的催化剂进行含有三键化合物的环加成反应。 （在公式中，J是氧原子、硫原子或BH3；R1和R2独立地是烷基、环烷基、芳基、烷氧基和芳氧基；a1和a2独立地为0或1；R3到R10独立地是烷基、环烷基、芳基、烷氧基和芳氧基；R3到R10中的两个可能形成环；*表示轴向不对称。）
• PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST
  申请人：Komiyama Masato

  公开号：US20110313169A1

  公开（公告）日：2011-12-22

  A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3).

  一种高效生产黄嘌呤氧化酶抑制剂或其中间体的方法，该抑制剂是治疗高尿酸血症的药物。该方法是一种新型偶联过程，包括将式（1）表示的化合物与式（2）表示的化合物在过渡金属化合物存在下进行偶联反应，从而获得式（3）表示的化合物。
• Axially Dissymmetric Bis(triaryl)phosphines in the Biphenyl series: Synthesis of (6,6′-dimethylbiphenyl-2,2′-diyl)bis(diphenylphosphine) (‘BIPHEMP’) and analogues, and their use in Rh(I)-catalyzed asymmetric isomerizations of<i>N,N</i>-diethylnerylamine
  作者：Rudolf Schmid、Marco Cereghetti、Bernd Heiser、Peter Schönholzer、Hans-Jürgen Hansen

  DOI：10.1002/hlca.19880710427

  日期：1988.6.15

  free diphosphine and of the derived Rh(I) complex, and for (−)-(R)- 13 by X-ray analysis of the derived Rh(I) complex. Configurational assignments for the substituted BIPHEMP analogues 1112 were achieved by means of 1H-NMR comparisons. The BIPHEMP ligand 10 and analogues 11, 12 and 13 are the first examples of optically active bis(triaylphosphines) containing the axially dissymmetric biphenyl moiety

  轴向不对称二膦（-）-（R）-和（+）-（S）-（6-6'-二甲基联苯-2,2'-二基）双（二苯基膦）（（-）-（R） -（10）和（+）-（S）-10 ;'BIPHEMP'）是从（R）-和（S）-6,6'-二甲基联苯-2,2'-二胺（（R）-和（S）-16）分别通过Sandmeyer反应，锂化和次膦酰基化。此外，外消旋的4,4'-二甲基-和4,4'-双（二甲基氨基）取代的类似物11和12分别合成了6,6'-桥接的类似物1,11-双（二苯基膦基）-5,7-二氢二苯并[ c，e ] oxepin （13）并拆分为光学纯的（R）-和（S）-对映异构体通过与二μ-chlorob络合是（[R）-2- [1-（二甲基氨基）乙基] pheny- ç ñ }二钯（II）（（- [R ）- 18）。二膦（S）-10和（R）-13以及两种衍生的阳离子Rh（I）配合物[Rh（（S）-10）（nbd）] BF
• Axially asymmetric ester compound and production method thereof
  申请人：Tanaka Ken

  公开号：US20090299076A1

  公开（公告）日：2009-12-03

  To provide an axially asymmetric optically active biaryl ester compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. There is provided a method for producing an axially asymmetric ester compound, comprising a cycloaddition of a compound having a triple bond with the use of a catalyst containing rhodium metal and an optically active bisphosphine.

  提供一种具有轴向不对称光学活性的双芳基酯化合物，可在传统方法中几乎不可或缺的光学分辨步骤之外轻松生产。提供了一种生产轴向不对称酯化合物的方法，包括使用含有铑金属和光学活性双膦催化剂对具有三键的化合物进行环加成。
• Process for producing an alcohol or a silyl ether thereof
  申请人：Shibasaki Masakatsu

  公开号：US20060199973A1

  公开（公告）日：2006-09-07

  A process for producing an alcohol or a silyl ether thereof of formula (4): wherein R 1 represents a hydrocarbon, a heterocyclic, or an alkoxycarbonyl group; R 2 represents hydrogen or CO 2 R; X represents an aryl or an alkenyl group of formula (3): and R 8 represents hydrogen or a silyl residue, by reacting a compound R 1 (C═O)R 2 with a silane (R 3 ) 2 R 4 Si—X, wherein R 3 and R 4 each represents an alkyl, an alkoxy, or an aryl group; in the presence of (i) a catalyst component containing copper fluoride or a catalyst component containing a copper compound and a fluoride and (ii) a bidentate phosphine compound or in the presence of a complex obtained from the foregoing components.

  生产醇或其硅基醚的方法，其分子式为（4）：其中R1代表烃基、杂环基或烷氧羰基；R2代表氢或CO2R；X代表分子式（3）的芳基或烯基；R8代表氢或硅基残基，通过将化合物R1(C═O)R2与硅烷（R3）2R4Si—X反应，其中R3和R4分别代表烷基、烷氧基或芳基，在（i）含有氟化铜的催化剂组分或含有铜化合物和氟化物的催化剂组分和（ii）双齿膦化合物的存在下，或在从上述组分得到的络合物的存在下。