4-(3-tert-Butyl-1-ethyl-8-oxo-1,6,7,8-tetrahydro-pyrazolo[4,3-e][1,4]diazepin-5-yl)benzonitrile | 349495-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-tert-Butyl-1-ethyl-8-oxo-1,6,7,8-tetrahydro-pyrazolo[4,3-e][1,4]diazepin-5-yl)benzonitrile
• 英文别名: 4-(3-Tert-butyl-1-ethyl-8-oxo-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-5-yl)benzonitrile
• CAS: 349495-99-4
• 化学式: C₁₉H₂₁N₅O
• 分子量: 335.409
• InChiKey: SQKPBGUSDKLINS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-tert-butyl-2-ethyl-4-nitro-2H-pyrazole-3-carboxylic acid 、 4-(2-氨基乙酰基)苯甲腈盐酸盐 以0.33 g (49%)的产率得到4-(3-tert-Butyl-1-ethyl-8-oxo-1,6,7,8-tetrahydro-pyrazolo[4,3-e][1,4]diazepin-5-yl)benzonitrile
  参考文献：
  名称：

  Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them

  摘要：

  这项发明涉及一种新型的取代吡唑并[4,3-e]-二氮杂环庚烷的一般式(I)，以及含有它们的药物组合物，它们作为药物的用途以及制备它们的方法。

  公开号：

  US20030171364A1

文献信息

• Pharmaceutical composition for preventing or treating a disease associated with an excess of IL-12-production
  申请人：——

  公开号：US20020119967A1

  公开（公告）日：2002-08-29

  This invention relates to the use of a PDE4 inhibitor or a pharmacologically acceptable salt thereof for manufacturing a medicament for preventing or treating a disease associated with an excess in IL-12 production.

  本发明涉及使用PDE4抑制剂或其药理学上可接受的盐来制造用于预防或治疗与IL-12过度产生相关的疾病的药物。
• Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them
  申请人：Burnouf Catherine

  公开号：US20050130957A1

  公开（公告）日：2005-06-16

  The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them.

  本发明涉及一种新的取代的嘧唑并[4,3-e]-二氮杂环己烷通式：以及含有它们的制药组合物，它们作为药物的使用以及制备它们的过程。
• Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1199074A1

  公开（公告）日：2002-04-24

  This invention relates to the use of a PDE4 inhibitor or a pharmacologically acceptable salt thereof for manufacturing a medicament for preventing or treating a disease associated with an excess in IL-12 production.

  本发明涉及使用 PDE4 抑制剂或其药理上可接受的盐制造药物，以预防或治疗与 IL-12 生成过多有关的疾病。
• NOVEL SUBTITUTED PYRAZOLO[4, 3-E]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1248787A2

  公开（公告）日：2002-10-16
• NOVEL SUBTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM
  申请人：Warner-Lambert Company LLC

  公开号：EP1248787B1

  公开（公告）日：2004-10-06