dimethyl (3R,7R)-7-[(1S,2S)-1-hydroxy-3-(4-methoxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-6-oxospiro[2.5]octane-2,2-dicarboxylate | 1111780-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl (3R,7R)-7-[(1S,2S)-1-hydroxy-3-(4-methoxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-6-oxospiro[2.5]octane-2,2-dicarboxylate
• CAS: 1111780-14-3
• 化学式: C₂₇H₃₇NO₉
• 分子量: 519.592
• InChiKey: OSXVDJNAPBSDPJ-MBEBEXRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  dimethyl (3R,7R)-7-[(1S,2S)-1-hydroxy-3-(4-methoxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-6-oxospiro[2.5]octane-2,2-dicarboxylate 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Total Synthesis of FR901483

  摘要：

  The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.

  DOI：

  10.1021/ol802870c
• 作为产物：
  描述：

  dimethyl (3S)-7-iodo-6-oxospiro[2.5]octane-2,2-dicarboxylate 、 N-tert-butyloxycarbonyl-O-methyl-tyrosal 在 三乙基硼 作用下， 以 正己烷 、 甲苯 为溶剂， 生成 dimethyl (3R,7R)-7-[(1S,2S)-1-hydroxy-3-(4-methoxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-6-oxospiro[2.5]octane-2,2-dicarboxylate
  参考文献：
  名称：

  Total Synthesis of FR901483

  摘要：

  The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.

  DOI：

  10.1021/ol802870c

文献信息

• Total Synthesis of FR901483
  作者：Cheryl A. Carson、Michael A. Kerr

  DOI：10.1021/ol802870c

  日期：2009.2.5

  The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.