| 882679-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 882679-83-6
• 化学式: C₂₅H₃₈N₂P₂
• 分子量: 428.538
• InChiKey: YQTJASGDHAQIQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以62%的产率得到
  参考文献：
  名称：

  C ‐Phosphoniophosphaalkenes as Precursors of 1σ ⁴ ,3σ ² ‐Diphosphaallenes: Scope and Limitations

  摘要：

  AbstractThe study of a general synthetic route to 1σ4,3σ2‐diphosphaallenes involving the reaction of LiHMDS with C‐phosphoniophosphaalkenes is reported. The choice of the base is critical since the precursors are highly electrophilic species that react cleanly with methyl‐, butyl‐, mesityl‐, or tert‐butyllithium to afford C‐phosphanylphosphonium ylides. The role of the substituents at the σ4‐phosphorus centre has alsobeen studied. The resulting phosphaallenes react cleanly with a Lewis acid and undergo [3+2] cycloaddition withazides to afford a five‐membered heterocycle in a three‐step process. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

  DOI：

  10.1002/ejic.200500014
• 作为产物：
  描述：

  lithium bis(trimethylsilyl)amide diethyl etherate 、 以 四氢呋喃 为溶剂， 以55%的产率得到
  参考文献：
  名称：

  C ‐Phosphoniophosphaalkenes as Precursors of 1σ ⁴ ,3σ ² ‐Diphosphaallenes: Scope and Limitations

  摘要：

  AbstractThe study of a general synthetic route to 1σ4,3σ2‐diphosphaallenes involving the reaction of LiHMDS with C‐phosphoniophosphaalkenes is reported. The choice of the base is critical since the precursors are highly electrophilic species that react cleanly with methyl‐, butyl‐, mesityl‐, or tert‐butyllithium to afford C‐phosphanylphosphonium ylides. The role of the substituents at the σ4‐phosphorus centre has alsobeen studied. The resulting phosphaallenes react cleanly with a Lewis acid and undergo [3+2] cycloaddition withazides to afford a five‐membered heterocycle in a three‐step process. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

  DOI：

  10.1002/ejic.200500014

文献信息

• <i>C</i> ‐Phosphoniophosphaalkenes as Precursors of 1σ ⁴ ,3σ ² ‐Diphosphaallenes: Scope and Limitations
  作者：David Martin、Heinz Gornitzka、Antoine Baceiredo、Guy Bertrand

  DOI：10.1002/ejic.200500014

  日期：2005.7

  AbstractThe study of a general synthetic route to 1σ4,3σ2‐diphosphaallenes involving the reaction of LiHMDS with C‐phosphoniophosphaalkenes is reported. The choice of the base is critical since the precursors are highly electrophilic species that react cleanly with methyl‐, butyl‐, mesityl‐, or tert‐butyllithium to afford C‐phosphanylphosphonium ylides. The role of the substituents at the σ4‐phosphorus centre has alsobeen studied. The resulting phosphaallenes react cleanly with a Lewis acid and undergo [3+2] cycloaddition withazides to afford a five‐membered heterocycle in a three‐step process. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)