3-trifluoromethoxyphenyl 4-fluorophenyl sulfide | 1361950-27-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-trifluoromethoxyphenyl 4-fluorophenyl sulfide
• 英文别名: 1-Fluoro-4-[3-(trifluoromethoxy)phenyl]sulfanylbenzene
• CAS: 1361950-27-7
• 化学式: C₁₃H₈F₄OS
• 分子量: 288.266
• InChiKey: MLIOGDAJMPXXPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对氟苯硫酚 、 3-(三氟甲氧基)苯硼酸 在 1,10-菲罗啉 、 四丁基氢氧化铵 、 水 、 氧气 、 copper(II) sulfate 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以58%的产率得到3-trifluoromethoxyphenyl 4-fluorophenyl sulfide
  参考文献：
  名称：

  Chan–Lam-Type S-Arylation of Thiols with Boronic Acids at Room Temperature

  摘要：

  In this work, an efficient CuSO4-catalyzed S-arylation of thiols with aryl and heteroaryl boronic acids at room temperature is established. This catalytic system can an tolerate a wide variety of thiols and arylboronic acids in the presence of only 5 mol % of CuSO4 as the catalyst and inexpensive 1,10-phen center dot H2O as the ligand. Moreover, this catalytic system used environment-friendly solvent (EtOH) and oxidant (oxygen).

  DOI：

  10.1021/jo300100x

文献信息

• Chan–Lam-Type S-Arylation of Thiols with Boronic Acids at Room Temperature
  作者：Hua-Jian Xu、Yong-Qiang Zhao、Teng Feng、Yi-Si Feng

  DOI：10.1021/jo300100x

  日期：2012.3.16

  In this work, an efficient CuSO4-catalyzed S-arylation of thiols with aryl and heteroaryl boronic acids at room temperature is established. This catalytic system can an tolerate a wide variety of thiols and arylboronic acids in the presence of only 5 mol % of CuSO4 as the catalyst and inexpensive 1,10-phen center dot H2O as the ligand. Moreover, this catalytic system used environment-friendly solvent (EtOH) and oxidant (oxygen).