2-phenylbenzo[b]furan-7-carboxylic acid | 116493-89-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-phenylbenzo[b]furan-7-carboxylic acid
• 英文别名: 2-phenylbenzofuran-7-carboxylic acid；2-phenyl-1-benzofuran-7-carboxylic acid
• CAS: 116493-89-1
• 化学式: C₁₅H₁₀O₃
• 分子量: 238.243
• InChiKey: RCBWMXHRGVANAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenylbenzo[b]furan-7-carboxylic acid 生成 2-piperidinoethyl 2-phenylbenzofuran-7-carboxylate
  参考文献：
  名称：

  IIDZIMA, IKUO;OSEHKI, MASAKATSU;SAJGA, YUTAKA;ISIDZUKA, TORU;NOSAKA, KUNI+

  摘要：

  DOI：
• 作为产物：
  描述：

  5-chloro-2-phenylbenzofuran-7-carboxylic acid 在 palladium-carbon ammonium formate 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 生成 2-phenylbenzo[b]furan-7-carboxylic acid
  参考文献：
  名称：

  Benzo-furan derivative

  摘要：

  一种新型苯并呋喃（或噻吩）衍生物的化学式如下：##STR1## 其中R.sup.1是氢原子、低碳烷基、环烷基、苯基-低碳烷基或取代或未取代的苯基，R.sup.2是氢原子、低碳烷基、酰基或苯基，R.sup.3是氢原子、卤素原子、硝基、低碳氧基、氨基或酰氨基，R.sup.4是下式的基团：##STR2## A是可选择地取代羟基的低碳烷基，B是单键或低碳烷基，R.sup.5和R.sup.6中的一个是氢原子或低碳烷基，另一个是低碳烷基或苯基-低碳烷基，或者R.sup.5和R.sup.6与相邻的氮原子结合形成杂单环基团，R.sup.7是低碳烷基，X是氧原子或硫原子，Y是氧原子、亚胺基、低碳烷基亚胺基或苯基-低碳烷基亚胺基以及其盐。所述化合物（I）及其盐对尿道膀胱反射收缩具有强大的抑制活性。

  公开号：

  US04829067A1

文献信息

• Benzofuran derivative and processes for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04882340A1

  公开（公告）日：1989-11-21

  A novel benzofuran derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkoxy group or a halogen atom, one of R.sup.2 and R.sup.3 is a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.2 and R.sup.3 combine together with adjacent nitrogen atom to form a heteromonocyclic group, Ring A is a substituted or unsubstituted phenyl group, Y is oxygen atom or sulfur atom and n is an integer of 2 or 3, or a pharmaceutically acceptable salt thereof is disclosed. The compound (I) or a pharmaceutically acceptable salt thereof has a potent inhibitory activity against reflective contractions of urinary bladder.

  一种新的苯并呋喃衍生物的化学式为：##STR1## 其中R.sup.1是氢原子，较低的烷氧基团或卤原子，R.sup.2和R.sup.3中的一个是较低的烷基团，另一个是较低的烷基团或苯基-较低的烷基团，或者R.sup.2和R.sup.3结合在一起与相邻的氮原子形成一个杂单环基团，环A是取代或未取代的苯基团，Y是氧原子或硫原子，n是2或3的整数，或其药学上可接受的盐。化合物(I)或其药学上可接受的盐对尿道膀胱反射性收缩具有强大的抑制活性。
• Bicyclic heterocyclic derivatives having .alpha..sub.1 -adrenergic and
  申请人：Recordati S.A., Chemical and Pharmaceutical Company

  公开号：US05474994A1

  公开（公告）日：1995-12-12

  This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding .alpha..sub.1 -adrenergic and 5HT.sub.1A serotonergic receptors, in vitro or in vivo.

  本发明提供了双环杂环衍生物及其药学上可接受的盐，用于治疗高血压、尿道和下泌尿道收缩以及其他疾病。这些化合物还可用于体内或体外结合α1-肾上腺素能和5HT1A-5-羟色胺能受体。
• Bicyclic heterocyclic derivatives having .alpha..sub.1 adrenergic and
  申请人：Recordati S.A., Chemical and Pharmaceutical Company

  公开号：US05605896A1

  公开（公告）日：1997-02-25

  This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding .alpha..sub.1 -adrenergic and 5HT.sub.1A serotonergic receptors, in vitro or in vivo.

  这项发明提供了用于治疗高血压、尿道和下尿道收缩以及其他疾病的双环杂环衍生物及其药用盐。这些化合物还可用于体外或体内结合α1-肾上腺素能和5HT1A-5-羟色胺能受体。
• A benzo-furan (or -thiophene) derivative and processes for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0270342A2

  公开（公告）日：1988-06-08

  Novel benzo-furan(or -thiophene) derivative of the formula: wherein R¹ is hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl-lower alkyl group or a substituted or unsubstituted phenyl group, R² is hydrogen atom, a lower alkyl group, an acyl group or phenyl group, R³ is hydrogen atom, a halogen atom, nitro group, a lower alkoxy group, amino group or an acylamino group, R⁴ is a group of the formula: A is a lower alkylene group optionally substituted with hydroxy group, B is single bond or a lower alkylene group, one of R⁵ and R⁶ is hydrogen atom or a lower alkyl group and the other is a lower alkyl group or a phenyl-­lower alkyl group, or R⁵ and R⁶ combine together with adjacent nitrogen atom to form a heteromonocyclic group, R⁷ is a lower alkyl group, X is oxygen atom or sulfur atom, Y is oxygen atom, imino group, a lower alkylimino group or a phenyl-lower alkylimino group and a salt thereof are disclosed. The invention also includes a process for making the compound (I). said compound (I) and a salt thereof have a potent inhibitory activity against reflective contraction of urinary bladder.

  式中的新型苯并呋喃（或噻吩）衍生物： 其中 R¹ 是氢原子、低级烷基、环烷基、苯基-低级烷基或取代或未取代的苯基，R² 是氢原子、低级烷基、酰基或苯基，R³ 是氢原子、卤素原子、硝基、低级烷氧基、氨基或酰氨基，R⁴ 是式中的一个基团： A 是可选被羟基取代的低级亚烷基，B 是单键或低级亚烷基，R⁵ 和 R⁶ 中的一个是氢原子或低级亚烷基，另一个是低级亚烷基或苯基-低级亚烷基、或 R⁵ 和 R⁶ 与相邻的氮原子结合在一起形成杂单环基，R⁷ 是低级烷基，X 是氧原子或硫原子，Y 是氧原子、亚氨基、低级烷基亚氨基或苯基-低级烷基亚氨基及其盐。 本发明还包括一种制造化合物（I）的工艺。所述化合物（I）及其盐对膀胱的反射性收缩具有强效抑制活性。
• A benzofuran derivative and processes for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0306226A2

  公开（公告）日：1989-03-08

  A novel benzofuran derivative of the formula: wherein R¹ is hydrogen atom, a lower alkoxy group or a halogen atom, one of R² and R³ is a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R² and R³ combine together with adjacent nitrogen atom to form a heteromonocyclic group, Ring A is a substituted or unsubstituted phenyl group, Y is oxygen atom or sulfur atom and n is an integer of 2 or 3, and processes thereof are disclosed. The compound (I) or a pharmaceutically acceptable salt thereof has a potent inhibitory activity against reflective contractions of urinary bladder.

  一种新型苯并呋喃衍生物，其式如下 其中 R¹ 是氢原子、低级烷氧基或卤原子，R² 和 R³ 中的一个是低级烷基，另一个是低级烷基或苯基-低级烷基，或者 R² 和 R³ 与相邻的氮原子结合在一起形成杂环基，环 A 是取代或未取代的苯基，Y 是氧原子或硫原子，n 是 2 或 3 的整数。 化合物(I)或其药学上可接受的盐对膀胱反射性收缩具有强效抑制活性。