N,N-二甲基喹喔啉-2-胺 | 35552-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: N,N-二甲基喹喔啉-2-胺
• 中文别名: N,N-二甲基-2-喹喔啉胺
• 英文名称: 2-Dimethylamino-chinoxalin
• 英文别名: 2-Dimethylaminoquinoxalin；dimethyl-quinoxalin-2-yl-amine；quinoxalin-2-yl-dimethyl-amine；Chinoxalin-2-yl-dimethyl-amin；N,N-dimethylquinoxalin-2-amine
• CAS: 35552-76-2
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: ZOWBRYALCDNHPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯喹恶啉 、 二甲胺 在 [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以88%的产率得到N,N-二甲基喹喔啉-2-胺
  参考文献：
  名称：

  Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine

  摘要：

  Simple and efficient Procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a Strong base, t-BuXPhos is employed as the supporting ligand; at 110 degrees C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L,Pd(0). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.137

文献信息

• Room‐Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System
  作者：Harshita Shet、Manisha Patel、Jyoti M. Waikar、Pavan M. More、Yogesh S. Sanghvi、Anant R. Kapdi

  DOI：10.1002/asia.202201006

  日期：2023.1.3

  relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room-temperature dimethylamination of chloroheteroarenes performed via the in-situ generation of dimethylamine using N,N-dimethylformamide (DMF) as precursor with a large substrate scope that includes various heteroarenes, purines as well as commercially relevant drugs such as

  二甲氨基功能在工业相关分子中具有重要意义，因此非常需要有效安装这些分子的方法。我们在此报告了使用N,N-二甲基甲酰胺 (DMF) 作为前体，通过原位生成二甲胺进行的氯代杂芳烃的高效室温二甲胺化，底物范围广泛，包括各种杂芳烃、嘌呤以及商业相关药物如六甲胺、氨吡嗪和嘌呤霉素前体。
• ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0985674A1

  公开（公告）日：2000-03-15

  An alkali metal- or alkali earth metal-containing organic compound (i) is reacted with a leaving group- and silicon- or germanium-containing compound (ii) in the presence of a nitrogen-containing aromatic heterocyclic compound. By such a method, it is possible to produce a silicon- or germanium-containing organic compound, for example, a cyclopentadienyl compound cross-linked by a silicon atom or a germanium atom, typically a cyclopentadienyl compound which is substituted with a substituted or unsubstituted silyl or germyl group, for a short time with a high yield.

  含碱金属或碱土金属的有机化合物(i)在含氮芳香杂环化合物存在下与离去基团和含硅或锗的化合物(ii)反应。通过这种方法，可以在短时间内以高产率生产出含硅或锗的有机化合物，例如，由硅原子或锗原子交联的环戊二烯基化合物，通常是由取代或未取代的硅基或锗基取代的环戊二烯基化合物。
• ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0985674B1

  公开（公告）日：2003-04-23
• PHARMACEUTICAL COMPOUNDS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20210107908A1

  公开（公告）日：2021-04-15

  The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
• US6255515B1
  申请人：——

  公开号：US6255515B1

  公开（公告）日：2001-07-03